Clinical Research Papers:

Effect of age on long-term outcomes after stroke with atrial fibrillation: a hospital-based follow-up study in China

Tao Wang, Bin Li _, Hongfei Gu, Yongzhong Lou, Xianjia Ning, Jinghua Wang and Zhongping An

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Oncotarget. 2017; 8:53684-53690. https://doi.org/10.18632/oncotarget.15729

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Tao Wang1, Bin Li1, Hongfei Gu1, Yongzhong Lou1, Xianjia Ning2,3,4 Jinghua Wang2,3,4 and Zhongping An5

1 Department of Neurology, Tianjin Haibin People’s Hospital, Tianjin, China

2 Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China

3 Department of Epidemiology, Tianjin Neurological Institute, Tianjin, China

4 Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin, China

5 Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China

Correspondence to:

Bin Li, email:

Zhongping An, email:

Xianjia Ning, email:

Keywords: ischemic stroke, atrial fibrillation, outcomes, risk factors, age

Received: October 27, 2016 Accepted: February 06, 2017 Published: February 25, 2017


Atrial fibrillation (AF) is an established predictor of poor outcomes after stroke. We aimed to assess the effect of age on outcomes at 1 year and 3 years in stroke patients with AF.We recruited acute ischemic stroke patients with AF between January 2006 and September 2014 in Tianjin, China. Clinical features and outcomes at 1 year and 3 years after stroke were compared between younger group and elderly group. Overall, 951 consecutive stroke patients with AF were included in this study. There was a higher mortality and dependency rate in the elderly group than in the young group at both 1 and 3 years after stroke. Recurrence rates were significantly higher in the elderly group than in the young group at 3 years after stroke. The higher risks of mortality and dependency in elderly patients remained unchanged, but disappeared in recurrence rates after adjusting for stroke subtype, severity, risk factors, and lifestyle. These findings suggest that it is crucial to highlight the treatment of elderly stroke patients with AF in order to reduce poor outcomes and to reduce the burden of AF in China.

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