Oncotarget

Clinical Research Papers:

A retrospective analysis of the utility of endocervical curettage in screening population

Yan Song, Yu-Qian Zhao, Ling Li, Qin-Jin Pan, Nan Li, Fang-Hui Zhao, Wen Chen, Xun Zhang _ and You-Lin Qiao

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Oncotarget. 2017; 8:50141-50147. https://doi.org/10.18632/oncotarget.15658

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Abstract

Yan Song1,*, Yu-Qian Zhao2,3,*, Ling Li1, Qin-Jin Pan1, Nan Li4, Fang-Hui Zhao3, Wen Chen3, Xun Zhang1 and You-Lin Qiao3

1 Department of Pathology, National Cancer Center, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

2 Department of Cancer Prevention and Treatment, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China

3 Department of Epidemiology, National Cancer Center, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

4 Department of Gynaecology, National Cancer Center, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

* These authors are equally contributed to this manuscript as co-first authors

Correspondence to:

Xun Zhang, email:

You-Lin Qiao, email:

Keywords: cervical intraepithelial neoplasia and cancer; screening; endocervical curettage; cytology; histopathology

Received: November 22, 2016 Accepted: January 24, 2017 Published: February 23, 2017

Abstract

The performance of endocervical curettage (ECC) is a dispute in population screening programs. Data of 3,460 women referred to colposcopy examination and had completed pathological results in the Shanxi Province Cervical Cancer Screening Study I and II were reviewed. Among them, 0.6% and 2.7% women were identified as the histopathological confirmed high-grade squamous intraepithelial lesion or worse (HSIL+) by ECC alone or both ECC and quadrants biopsy respectively. Age, cytology, and colposcopy impression are the impact factors for the HSIL+ yield of ECC (P<0.05). The age-adjusted odds ratio for cytology and colposcopic impression were 5.283 (95%CI: 3.989-6.997) and 3.609 (95%CI: 2.910-4.476) respectively. In low-grade squamous intraepithelial lesion cytology and abnormal colposcopy, no additional HSIL+ was found by ECC. In low-grade squamous intraepithelial lesion cytology but normal colposcopy, the additional yield was 0.6%, 0.8% and 1.1% for the three age groups respectively. In high-grade squamous intraepithelial lesion or worse cytology, the additional HSIL+ yield by ECC ranged between 1.4% and 6.6%. We conclude that the performance of ECC increases with age, the severity of cytology, and colposcopic impression. For women 35 years and older, ECC should be performed if the cytological finding is high-grade or worse in cervical cancer screening program.


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