Clinical Research Papers:

Association between coronary heart disease and erectile dysfunction in Chinese Han population

Guo-Xiang Tian, Sheng Li, Tong-Zu Liu, Xian-Tao Zeng, Wan-Lin Wei and Xing-Huan Wang _

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Oncotarget. 2017; 8:55562-55566. https://doi.org/10.18632/oncotarget.15654

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Guo-Xiang Tian1,2,3, Sheng Li1,2, Tong-Zu Liu1,2, Xian-Tao Zeng2, Wan-Lin Wei3 and Xing-Huan Wang1,2

1 Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China

2 Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China

3 Department of Cardiology and 4th Cadres Ward, General Hospital of Beijing Military Command, Beijing, China

Correspondence to:

Xing-Huan Wang, email:

Keywords: case-control study; China; coronary heart disease; erectile dysfunction

Received: December 08, 2016 Accepted: February 13, 2017 Published: February 23, 2017


To investigate the association between coronary heart disease (CHD) and erectile dysfunction (ED) in Chinese Han population. Patients who went to the andrological out-patient clinic of our hospital between August 1, 2015 and May 1, 2016 and met all eligible criteria were enrolled in this study. The patients diagnosed as ED using self-administered International Index of Erectile Function-5 (IIEF-5) questionnaire were considered as case group and others were considered as control. The cases were categorized as mild, moderate, and severe ED. Subjects were interviewed for the history of CHD. Uni- and multivariate logistic regression models were used to calculate odds ratios (ORs) and corresponding 95% confidence intervals (CIs) using the SPSS 18.0 software. A total of 240 participants (56 ED patients and 184 controls) were enrolled. CHD prevalence was higher in cases without statistical significance (OR = 1.20, 95%CI = 0.63-2.29; p = 0.58). Results of adjusted analysis also showed a non-significantly increased risk (OR = 1.25, 95%CI = 0.55-2.85; p = 0.59). Stratified analysis by severity of ED revealed similar results. This study suggests no significant association exists between CHD and ED in Chinese Han population.

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