Research Papers:

Interleukin-1β rs1143627 polymorphism with susceptibility to periodontal disease

Wei Huang _, Bing-Yang He, Jun Shao, Xiao-Wei Jia and Ya-Di Yuan

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Oncotarget. 2017; 8:31406-31414. https://doi.org/10.18632/oncotarget.15612

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Wei Huang1,*, Bing-Yang He2,*, Jun Shao3,*, Xiao-Wei Jia3 and Ya-Di Yuan3

1Department of Stomatology, Zhuhai People’s Hospital, Zhuhai Hospital Affiliated With Jinan University, Zhuhai 519099, Guangdong Province, China

2Department of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China

3Department of Stomatology, Guangzhou Hospital of Integrated Traditional and West Medicine, Guangzhou 510800, Guangdong Province, China

*Wei Huang, Bing-Yang He and Jun Shao are the co-first authors

Correspondence to:

Wei Huang, email: [email protected]

Keywords: interleukin-1, periodontitis, periodontal disease, meta-analysis, polymorphism

Received: December 12, 2016    Accepted: January 17, 2017    Published: February 22, 2017


Association between interleukin-1 beta (IL-1β) rs1143627 polymorphism and periodontal disease susceptibility was inconsistent; hence we performed this meta-analysis to explore the precise correlation between them. The degree of association was appraised through calculating pooled odds ratio (OR) and its 95% confidence interval (CI). The databases known as PubMed, Embase, and Chinese National Knowledge Infrastructure were searched up to October 26, 2016. A total of 8 eligible case-control studies were finally included, which involved 229 aggressive periodontitis patients, 382 chronic periodontitis patients, and 555 healthy controls. All the five genetic models revealed a non-significant association between IL-1β rs1143627 polymorphism and periodontal disease susceptibility (TT vs. CC: OR = 1.22, 95% CI = 0.80-1.87; CT+TT vs. CC: OR = 0.66, 95% CI = 0.44-1.01; TT vs. CT + CC: OR = 1.19, 95% CI = 0.81-1.74; T vs. C: OR = 0.92, 95% CI = 0.81-1.12; CT vs. CC: OR = 0.92, 95% CI = 0.69-1.23). Sensitivity analyses indicated that the results were robust and the subgroup analyses reached similar conclusions. IL-1β rs1143627 polymorphism is not related to periodontal disease susceptibility in the overall population based on the current evidence, but further studies are required in more large scale sample size with risk factor adjusted.

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