Clinical Research Papers:

Endoscopic diagnosis of primary anorectal melanoma

Sheng Wang, Siyu Sun _, Xiang Liu, Nan Ge, Guoxin Wang, Jintao Guo, Wen Liu and Shupeng Wang

PDF  |  HTML  |  How to cite

Oncotarget. 2017; 8:50133-50140. https://doi.org/10.18632/oncotarget.15495

Metrics: PDF 2040 views  |   HTML 2297 views  |   ?  


Sheng Wang1, Siyu Sun1, Xiang Liu1, Nan Ge1, Guoxin Wang1, Jintao Guo1, Wen Liu1 and Shupeng Wang1

1 Endoscopic Center, Shengjing Hospital of China Medical University, Shenyang, China

Correspondence to:

Siyu Sun, email:

Keywords: anorectal melanoma, colonoscopy, endoscopic ultrasound

Received: November 17, 2016 Accepted: February 07, 2017 Published: February 18, 2017


Objective: The present study retrospectively analyzed case data from 12 patients diagnosed with anorectal melanoma, with the purpose of identifying key diagnostic features at endoscopy.

Materials and Methods: Images from colonoscopy were reviewed for all patients in order to establish the endoscopic features of primary anorectal melanoma. For the patients whose colonoscopic examinations included endoscopic ultrasound, images were examined to characterize lesions and the depth of infiltration, the results of which were compared with pathological findings after operative resection.

Results: At colonoscopy, superficial melanin pigmentation was identified in 10 patients with anorectal melanoma, with morphology including spots, patches, or sheets of pigmentation. In patients who underwent endoscopic ultrasound, lesions appeared as masses on the mucosal side with inhomogeneous or low-level internal echoes or ulcer-type lesions invading the muscularis propria. Lesions diagnosed as anorectal melanoma also demonstrated irregular margins and varying degrees of submucosal infiltration. Infiltration depth of melanoma via endoscopic ultrasound (EUS) was concordant with surgical pathology results in 100% of patients.

Conclusion: Colonoscopy combined with biopsy and subsequent pathological examination can accurately diagnose primary anorectal melanoma. Moreover, EUS is a reliable tool for assessing the depth of infiltration of this disease.

Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 15495