Research Papers:

The role of hesperetin on osteogenesis of human mesenchymal stem cells and its function in bone regeneration

Deting Xue, Erman Chen, Wei Zhang, Xiang Gao, Shengdong Wang, Qiang Zheng, Zhijun Pan, Hang Li _ and Ling Liu

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Oncotarget. 2017; 8:21031-21043. https://doi.org/10.18632/oncotarget.15473

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Deting Xue1, Erman Chen1, Wei Zhang1, Xiang Gao1, Shengdong Wang1, Qiang Zheng1, Zhijun Pan1, Hang Li1, Ling Liu2

1Department of Orthopaedics, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, P.R. China

2Department of Nephrology, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou 310007, P.R. China

Correspondence to:

Hang Li, email: [email protected]

Ling Liu, email: [email protected]

Keywords: hesperetin, mesenchymal stem cells, bone regeneration, osteogenesis, gelatin sponge scaffold

Received: January 04, 2017     Accepted: February 08, 2017     Published: February 18, 2017


Hesperetin has been suggested to be involved in bone strength. We aimed to investigate the effects of hesperetin on the osteogenic differentiation of human mesenchymal stem cells and its related mechanisms. We showed that hesperetin promoted osteogenic differentiation of human mesenchymal stem cells in vitro. It potentially exerts its effects via the ERK and Smad signaling pathways. Using a rat osteotomy model, we showed that human mesenchymal stem cells combined with a hesperetin/gelatin sponge scaffold resulted in accelerated fracture healing in vivo. Due to the low cost of hesperetin, it could be used as a growth factor for bone tissue engineering or surgical fracture treatment.

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