MSMB gene rs10993994 polymorphism increases the risk of prostate cancer
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Tao Peng1, Lifeng Zhang2, Lijie Zhu1, Yuan-Yuan Mi1
1Department of Urology, The Third Affiliated Hospital of Nantong University, Wuxi, PR China
2Department of Urology, Changzhou No.2 People′s Hospital Affiliated to Nanjing Medical University, Changzhou, Jiangsu Province, China
Lifeng Zhang, email: email@example.com
Lijie Zhu, email: firstname.lastname@example.org
Yuan-Yuan Mi, email: email@example.com
Keywords: MSMB, prostate cancer, rs10993994, meta-analysis, single nucleotide polymorphism
Received: December 01, 2016 Accepted: January 11, 2017 Published: February 14, 2017
Genome-wide association studies (GWASs) identified microseminoprotein-β (MSMB) gene rs10993994 polymorphism was significantly associated with prostate cancer (PC) risk. However, the association between MSMB gene rs10993994 polymorphism and PC risk remains controversial. Therefore, we performed a systematic review and meta-analysis by searching in the databases of PubMed, and Embase. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by using fixed-effect or random-effect models. A total of 11 publications containing 13 case-control studies for rs10993994 polymorphism were included in our analysis. Our data indicated that MSMB gene rs10993994 polymorphism was associated with an increased risk of PC. Stratification analyses of ethnicity suggested rs10993994 polymorphism increased the risk of PC among Caucasians, but not among Asians. In conclusion, this meta-analysis indicates that MSMB gene rs10993994 polymorphism increases the risk of PC.
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