Grifolin exhibits anti-cancer activity by inhibiting the development and invasion of gastric tumor cells
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Zijian Wu1, Ying Li2
1Tianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China
2Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
Zijian Wu, email: [email protected]
Ying Li, email: [email protected]
Keywords: gastric cancer, grifolin, natural anti-cancer product, apoptosis, cancer invasion
Received: October 20, 2016 Accepted: November 24, 2016 Published: February 10, 2017
Grifolin, a natural product isolated from the mushroom Albatrellus confluens, has been reported to be a potent anti-cancer agent in nasopharyngeal carcinoma and osteosarcoma. The data obtained in this study revealed that grifolin is capable of inhibiting the growth and invasion of gastric cancer cells by inducing apoptosis and suppressing the ERK1/2 pathway. Our results support the potent utility of grifolin as an anti-tumor lead compound against gastric cancer cells.
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