Research Papers:

Grifolin exhibits anti-cancer activity by inhibiting the development and invasion of gastric tumor cells

Zijian Wu _ and Ying Li

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Oncotarget. 2017; 8:21454-21460. https://doi.org/10.18632/oncotarget.15250

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Zijian Wu1, Ying Li2

1Tianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China

2Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China

Correspondence to:

Zijian Wu, email: [email protected]

Ying Li, email: [email protected]

Keywords: gastric cancer, grifolin, natural anti-cancer product, apoptosis, cancer invasion

Received: October 20, 2016     Accepted: November 24, 2016     Published: February 10, 2017


Grifolin, a natural product isolated from the mushroom Albatrellus confluens, has been reported to be a potent anti-cancer agent in nasopharyngeal carcinoma and osteosarcoma. The data obtained in this study revealed that grifolin is capable of inhibiting the growth and invasion of gastric cancer cells by inducing apoptosis and suppressing the ERK1/2 pathway. Our results support the potent utility of grifolin as an anti-tumor lead compound against gastric cancer cells.

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PII: 15250