Clinical Research Papers:
Relationship of thyroid function with intracranial arterial stenosis and carotid atheromatous plaques in ischemic stroke patients with euthyroidism
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Junfeng Liu1,*, Xiaoyang Cui2,*, Deren Wang1, Simiao Wu1, Yao Xiong1, Shihong Zhang1, Bo Wu1 and Ming Liu1
1 Department of Neurology, Stroke Clinical Research Unit, West China Hospital, Sichuan University, Chengdu, P.R. China
2 Department of Respiratory and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, P.R. China
* The first two authors contributed equally to this work
Ming Liu, email:
Keywords: free triiodothyronine, free thyroxine, thyroid-stimulating hormone, intracranial artery stenosis, carotid atheromatous plaques
Received: October 02, 2016 Accepted: January 16, 2017 Published: January 28, 2017
This study aimed to help clarify the possible relationships of thyroid function with intracranial arterial stenosis or carotid atheromatous plaques in ischemic stroke patients with euthyroidism. We retrospectively reviewed the medical records of a consecutive series of ischemic stroke patients prospectively entered into the Chengdu Stroke Registry between February 2010 and March2012. We performed univariate and multivariate analysis to assess possible relationships of thyroid function with intracranial artery stenosis or carotid atheromatous plaques. Of the 172 patients analyzed (42 women; 61.7 ± 14.0 years old), 62 (32.0%) had carotid atheromatous plaques, and 81 (47.1%) had intracranial artery stenosis. Free thyroxine levels were lower in patients with carotid atheromatous plaques than in patients without plaques (15.80±2.09 vs. 16.92±2.69, P = 0.005).After adjusting for age, gender, hyperlipidemia, and previous smoking, free thyroxine levels were independently associated with carotid atheromatous plaques (OR 0.73, 95% CI 0.54-0.99, P = 0.04). In contrast, thyroid function indicators showed no associations with intracranial arterial stenosis. In conclusion, low free thyroxine levels were independently associated with carotid atheromatous plaques in ischemic stroke patients with euthyroidism, but thyroid function indicators were not associated with intracranial artery stenosis.
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