Oncotarget

Research Papers:

Elevated NF-κB signaling in Asherman syndrome patients and animal models

Xiangzhen Wang, Nana Ma, Qiannan Sun, Chenlingzi Huang, Yanmei Liu and Xin Luo _

PDF  |  HTML  |  How to cite  |  Order a Reprint

Oncotarget. 2017; 8:15399-15406. https://doi.org/10.18632/oncotarget.14853

Metrics: PDF 1380 views  |   HTML 2157 views  |   ?  


Abstract

Xiangzhen Wang1,2, Nana Ma3, Qiannan Sun4, Chenlingzi Huang1, Yanmei Liu5, Xin Luo1

1The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China, 510630

2Nanshan Maternity and Child Healthcare Hospital of Shenzhen, Shenzhen, Guangdong, China, 518052

3The First Affiliated Hospital of Xinxiang medical college of Henan, Xinxiang, Henan, China, 453100

4Changzhi City People’s Hospital of Shanxin Medical University Affiliated Hospital, Changzhi, Shanxi, China, 046000

5Huadu District, Guangzhou City People’s Hospital, Guangzhou, Guangdong, China, 510630

Correspondence to:

Xiangzhen Wang, email: 1093456531@qq.com

Xin Luo, email: tluox@126.com

Keywords: NF-κB, Asherman syndrome, intrauterine adhesion, pregnancy, uterine disease

Received: October 09, 2016     Accepted: January 09, 2017     Published: January 27, 2017

ABSTRACT

Asherman syndrome (intrauterine adhesion) is often associated with menstrual abnormalities, infertility and recurrent miscarriage in female. Currently the molecular mechanism regulating the pathogenesis of Asherman syndrome is not known. Here we revealed that the inflammatory factor NF-κB expression is significantly elevated in the endometrial samples of Asherman syndrome patients. To further study the molecular mechanisms, we established an Asherman syndrome rat model and confirmed the important role of NF-κB in the pathogenesis of Asherman syndrome. In addition, our rat model provided direct evidence that intrauterine adhesion results in impaired pregnancy, supporting the clinical association between intrauterine adhesion and mis-regulated pregnancy. Our result identified NF-κB as a novel pathogenesis factor of Asherman syndrome and provided new insights for the prevention and treatment of intrauterine adhesions in Asherman syndrome patients.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
PII: 14853