Clinical Research Papers:

Esophageal luminal stenosis is an independent prognostic factor in esophageal squamous cell carcinoma

Yu-Shang Yang, Wei-Peng Hu, Peng-Zhi Ni, Wen-Ping Wang, Yong Yuan and Long-Qi Chen _

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Oncotarget. 2017; 8:43397-43405. https://doi.org/10.18632/oncotarget.14762

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Yu-Shang Yang1, Wei-Peng Hu1, Peng-Zhi Ni1, Wen-Ping Wang1, Yong Yuan1 and Long-Qi Chen1

1 Department of Thoracic Surgery, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, Sichuan, China

Correspondence to:

Long-Qi Chen, email:

Keywords: esophageal cancer, outcomes, endoscopy, esophagectomy

Received: September 20, 2016 Accepted: January 10, 2017 Published: January 19, 2017


Background. Predictive value of preoperative endoscopic characteristic of esophageal tumor has not been fully evaluated. The aim of this study is to investigate the impact of esophageal luminal stenosis on survival for patients with resectable esophageal squamous cell carcinoma (ESCC).

Methods. The clinicopathologic characteristics of 623 ESCC patients who underwent curative resection as the primary treatment between January 2005 and April 2009 were retrospectively reviewed. The esophageal luminal stenosis measured by endoscopy was defined as a uniform measurement preoperatively. The impact of esophageal luminal stenosis on patients’ overall survival (OS) and relation with other clinicopathological features were assessed. A Cox regression model was used to identify prognostic factors.

Results. The results showed that OS significantly decreased in patients with manifest stenotic tumor compared with patients without luminal obstruction (P<0.05). Considerable esophageal luminal stenosis was associated with a higher T stage, longer tumor length, and poorer differentiation (all P<0.05). In multivariate survival analysis, esophageal luminal stenosis remained as an independent prognostic factor for OS (P= 0.036).

Conclusions. Esophageal luminal stenosis could have a significant impact on the OS in patients with resected ESCC and may provide additional prognostic value to the current staging system before any cancer-specific treatment.

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