Prognostic value of abnormally expressed lncRNAs in ovarian carcinoma: a systematic review and meta-analysis
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Ping Luo1, Xue-Fang Liu1, Ying-Chao Wang1, Nan-Di Li1, Shen-Jun Liao1, Ming-Xia Yu1, Chun-Zi Liang1 and Jian-Cheng Tu1
1 Department of Clinical Laboratory Medicine & Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan, China
Jian-Cheng Tu, email:
Keywords: long noncoding RNAs, ovarian cancer, overall survival, prognosis, meta-analysis
Received: November 15, 2016 Accepted: January 11, 2017 Published: January 19, 2017
Ovarian cancer (OC) is the most deadly gynecological cancer and it is urgently needed to find a new marker for the progress of OC. Many long noncoding RNAs (lncRNAs) have been reported to be aberrantly expressed in ovarian carcinoma, and may serve as prognostic markers. Therefore, we conducted this meta-analysis to gain a better understanding of the prognostic value of lncRNAs in patients with varian carcinoma. We systematically searched PubMed, EMBASE, and Web of Science. A total of 13 eligible studies, including 10 on clinicopathological features, 13 on prognosis were identified. Pooled hazard ratios (HRs) or odds ratios (OR) and 95% confidence intervals (95% CIs) were calculated using random- or fixed-effects models. Our results revealed that the increased expressions of 8 lncRNAs were associated with poor prognosis and the decreased expressions of 5 lncRNAs were related to poor prognosis in ovarian carcinoma. High HOTAIR expression was associated with shorter overall survival in ovarian cancer (pooled HR: 2.05, 95% CI: 1.51-2.77, P < 0.001). In conclusion, our meta-analysis suggested that LncRNAs could function as potential prognostic markers for ovarian cancer patients and high expression HOTAIR was associated with shorter overall survival in ovarian cancer.
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