RNA binding motif protein 3: a potential biomarker in cancer and therapeutic target in neuroprotection

Ren-Bin Zhou, Xiao-Li Lu, Chen-Yan Zhang and Da-Chuan Yin _

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Oncotarget. 2017; 8:22235-22250. https://doi.org/10.18632/oncotarget.14755

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Ren-Bin Zhou1, Xiao-Li Lu1, Chen-Yan Zhang1 and Da-Chuan Yin1

1 Key Laboratory for Space Bioscience & Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi, PR China

Correspondence to:

Da-Chuan Yin, email:

Keywords: RNA binding protein 3, cancer, biomarker, neuroprotection

Received: September 24, 2016 Accepted: January 10, 2017 Published: January 19, 2017


RNA binding motif 3 (RBM3) is a highly conserved cold-induced RNA binding protein that is transcriptionally up-regulated in response to harsh stresses. Featured as RNA binding protein, RBM3 is involved in mRNA biogenesis as well as stimulating protein synthesis, promoting proliferation and exerting anti-apoptotic functions. Nowadays, accumulating immunohistochemically studies have suggested RBM3 function as a proto-oncogene that is associated with tumor progression and metastasis in various cancers. Moreover, emerging evidences have also indicated that RBM3 is equally effective in neuroprotection. In the present review, we provide an overview of current knowledge concerning the role of RBM3 in various cancers and neuroprotection. Additionally, its potential roles as a promising diagnostic marker for cancer and a possible therapeutic target for neuro-related diseases are discussed.

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