Oncotarget

Research Papers:

The expression of podoplanin protein is a diagnostic marker to distinguish the early infiltration of esophageal squamous cell carcinoma

Guangyong Chen, Rui Xu, Bing Yue, Xue Mei, Peng Li, Xiaoge Zhou, Shoufang Huang, Liping Gong and Shutian Zhang _

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Oncotarget. 2017; 8:19013-19020. https://doi.org/10.18632/oncotarget.14596

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Abstract

Guangyong Chen1, Rui Xu1, Bing Yue1, Xue Mei1, Peng Li2, Xiaoge Zhou1, Shoufang Huang1, Liping Gong3, Shutian Zhang2

1Department of Pathology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing, 10050 China

2Department of Gastroenterology and Hepatology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing, 10050 China

3Department of Pathology, Basic Medical College, Capital Medical University, Beijing, 100069 China

Correspondence to:

Shutian Zhang, email: [email protected]

Keywords: podoplanin, esophageal squamous cell carcinoma

Received: October 24, 2016     Accepted: October 28, 2016     Published: January 11, 2017

ABSTRACT

The esophageal squamous cell carcinoma (ESCC) is usually develped from low-grade intraepithelial neoplasia (LGIEN) and high-grade intraepithelial neoplasia (HGIEN) to infiltrative squamous cell carcinoma. Till now, it remains hard to screen for infiltration at earlier stages, especially the differentiation between HGEIN and early infiltrative carcinoma. The purpose of this study is to determine a role of podoplanin in differentiating between HGEIN and early infiltrative squamous cell carcinoma. Totally 133 patients pathologically diagnosed with early ESCC and/or precancerous lesions were enrolled.The EnVision two-step IHC staining technique was applied using the monoclonal mouse anti-human Podoplanin antibody (clone number: D2-40). The expressions of PDPN protein on the basal layer of squamous epithelium lesions could be divided into three different patterns: complete type, incomplete (non-continuous) type, or missing type. A diagnosis of HGEIN can be made if the basal layer showed non-continuous or complete expression of PDPN and a diagnosis of early infiltration can be made if the expression of PDPN is completely missing. Our study confirmed that PDPN was a potential biomarker to identify the presence of early infiltrative squamous cell carcinoma.


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