Research Papers:

This article has been corrected. Correction in: Oncotarget. 2017; 8:48525.

Asthma and the risk of lung cancer: a meta-analysis

Yan-Liang Qu, Jun Liu, Li-Xin Zhang, Chun-Min Wu, Ai-Jie Chu, Bao-Lei Wen, Chao Ma, Xu-yan Yan, Xin Zhang, De-Ming Wang, Xin Lv and Shu-Jian Hou _

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Oncotarget. 2017; 8:11614-11620. https://doi.org/10.18632/oncotarget.14595

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Yan-Liang Qu1,*, Jun Liu2,*, Li-Xin Zhang1, Chun-Min Wu1, Ai-Jie Chu1, Bao-Lei Wen1, Chao Ma1, Xu-yan Yan1, Xin Zhang1, De-Ming Wang1, Xin Lv2, Shu-Jian Hou3

1Department of Anesthesiology, Hospital of PLA, Qingdao 266071, Shandong, China

2Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China

3Department of Hand Surgery, Hospital of PLA, Qingdao 266071, Shandong, China

*These authors contributed equally to this work

Correspondence to:

Xin Lv, email: [email protected]

Shu-Jian Hou, email: [email protected]

Keywords: asthma, lung cancer, association, meta-analysis

Received: October 11, 2016     Accepted: November 18, 2016     Published: January 11, 2017


Some studies found that there was a significant association between asthma and the risk of lung cancer. However, the results are inconclusive. Therefore, we performed a meta-analysis. We searched the electronic databases for all relevant articles. Odds ratio (OR) with 95% confidence interval (CI) were used to calculate the strength of the association between asthma and lung cancer risk. Asthma was significantly associated with the increased risk of lung cancer (OR = 1.44; 95% CI 1.31–1.59; P < 0.00001; I2 = 83%). Additionally, asthma patients without smoking also had the increased lung cancer risk. In the subgroup analysis of race and gender, Caucasians, Asians, male, and female patients with asthma showed the increased risk of lung cancer. However, asthma was not significantly associated with lung adenocarcinoma risk. In the stratified analysis by asthma definition, significant associations were found between asthma and lung cancer in self-reported subgroup, questionnaire subgroup, and register databases subgroup. However, no significant association was observed in physician-diagnosed asthma subgroup. In conclusion, this meta-analysis suggested that asthma might be significantly associated with lung cancer risk.

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