Asthma and the risk of lung cancer: a meta-analysis
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Yan-Liang Qu1,*, Jun Liu2,*, Li-Xin Zhang1, Chun-Min Wu1, Ai-Jie Chu1, Bao-Lei Wen1, Chao Ma1, Xu-yan Yan1, Xin Zhang1, De-Ming Wang1, Xin Lv2, Shu-Jian Hou3
1Department of Anesthesiology, Hospital of PLA, Qingdao 266071, Shandong, China
2Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China
3Department of Hand Surgery, Hospital of PLA, Qingdao 266071, Shandong, China
*These authors contributed equally to this work
Xin Lv, email: firstname.lastname@example.org
Shu-Jian Hou, email: email@example.com
Keywords: asthma, lung cancer, association, meta-analysis
Received: October 11, 2016 Accepted: November 18, 2016 Published: January 11, 2017
Some studies found that there was a significant association between asthma and the risk of lung cancer. However, the results are inconclusive. Therefore, we performed a meta-analysis. We searched the electronic databases for all relevant articles. Odds ratio (OR) with 95% confidence interval (CI) were used to calculate the strength of the association between asthma and lung cancer risk. Asthma was significantly associated with the increased risk of lung cancer (OR = 1.44; 95% CI 1.31–1.59; P < 0.00001; I2 = 83%). Additionally, asthma patients without smoking also had the increased lung cancer risk. In the subgroup analysis of race and gender, Caucasians, Asians, male, and female patients with asthma showed the increased risk of lung cancer. However, asthma was not significantly associated with lung adenocarcinoma risk. In the stratified analysis by asthma definition, significant associations were found between asthma and lung cancer in self-reported subgroup, questionnaire subgroup, and register databases subgroup. However, no significant association was observed in physician-diagnosed asthma subgroup. In conclusion, this meta-analysis suggested that asthma might be significantly associated with lung cancer risk.
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