Oncotarget

Research Papers:

The regulator of calcineurin 1 (RCAN1) inhibits nuclear factor kappaB signaling pathway and suppresses human malignant glioma cells growth

Xin Chen, Yuanyuan Hu, Shuo Wang and Xiulian Sun _

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Oncotarget. 2017; 8:12003-12012. https://doi.org/10.18632/oncotarget.14479

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Abstract

Xin Chen1,*, Yuanyuan Hu2,*, Shuo Wang1, Xiulian Sun2

1Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, P. R. China; China National Clinical Research Center for Neurological Diseases, Beijing, P. R. China; Center of Stroke, Beijing Institute for Brain Disorders, Beijing, P. R. China; Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing, P. R. China

2Brain Research Institute, Qilu Hospital of Shandong University, Jinan, Shandong Province, China

*These authors have contributed equally to this work

Correspondence to:

Xiulian Sun, email: [email protected]

Shuo Wang, email: [email protected]

Keywords: RCAN1, suppress, apoptosis, glioma, NF-κB signaling

Received: September 26, 2016     Accepted: December 20, 2016     Published: January 04, 2017

ABSTRACT

Nuclear factor-kappaB (NF-κB) has a vital role in cell survival and inhibition of NF-κB had proven to be an efficient therapeutic pathway for various cancers though little is known about the underlying mechanism. Previously we identified regulator of calcineurin 1 (RCAN1) as an endogenous inhibitor of NF-κB signaling pathway in lymphoma. In the present study, we have solid data to show that RCAN1 can inhibit the nuclear translocation of NF-κB protein then affect the activity of NF-κB signaling pathway in glioma cells. Overexpression of RCAN1 markedly reduced glioma cells viability. We further found that the suppressing glioma cell growth was closely related to the pro-apoptosis effect, not by inhibiting proliferation by the arrest of cell cycle. Our study implicated a novel therapeutic approach for glioma by RCAN1 through inhibition of NF-κB signaling.


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