Oncotarget

Research Papers:

Genetic polymorphisms in TERT are associated with increased risk of esophageal cancer

Yifei Wu, Mengdan Yan, Jing Li, Jingjie Li, Zhengshuai Chen, Peng Chen, Bin Li, Fulin Chen, Tianbo Jin and Chao Chen _

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Oncotarget. 2017; 8:10523-10530. https://doi.org/10.18632/oncotarget.14451

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Abstract

Yifei Wu1,*, Mengdan Yan1,2,*, Jing Li1,2, Jingjie Li1,2, Zhengshuai Chen1,2, Peng Chen1,2,3, Bin Li1,2, Fulin Chen1, Tianbo Jin1,2, Chao Chen1

1Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi’an, Shaanxi 710069, China

2Xi’an Tiangen Precision Medical Institute, Xi’an, Shaanxi 710075, China

3Institution of Basic Medical Science, Xi'an Medical University, Xi’an, Shaanxi 710021, China

*These authors have contributed equally to this work

Correspondence to:

Tianbo Jin, email: jtianbo@163.com.com

Chao Chen, email: chaochenxida@163.com

Keywords: TERT, SNP, esophageal cancer, susceptibility, northwest Chinese population

Received: August 26, 2016     Accepted: December 13, 2016     Published: January 2, 2017

ABSTRACT

Single nucleotide polymorphisms (SNPs) in TERT may be associated with susceptibility to esophageal cancer. In this study, we analyzed the association between TERT SNPs and risk of esophageal cancer in 386 esophageal cancer patients and 495 healthy subjects from the Xi’an area of China. Of the four SNPs examined, rs10069690 and rs2242652 were correlated with esophageal cancer risk. Additionally, after adjusting for age and gender, the “Trs10069690Ars2242652”, “Trs10069690Grs2242652” haplotypes were associated with an increased risk of esophageal cancer, while the and “Crs10069690Grs2242652” haplotype was associated with a decreased risk of esophageal cancer. These findings suggest that TERT polymorphisms may contribute to the development of esophageal cancer.


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