Associations between genetic variants in immunoregulatory genes and risk of non-Hodgkin lymphoma in a Chinese population
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Xibiao Ye1,2,3, Kaiqiong Zhao3,4, Cuie Wu5, Pingzhao Hu3,4, Hua Fu5
1Department of Community Health Sciences, College of Medicine, Faculty of Health Sciences, University of Manitoba, Canada
2Vaccine and Drug Evaluation Centre, University of Manitoba, Canada
3Centre for Healthcare Innovation, University of Manitoba, Winnipeg, Manitoba, Canada
4Department of Biochemistry and Medical Genetics, College of Medicine, Faculty of Health Sciences, University of Manitoba, Canada
5School of Public Health, Fudan University, Shanghai, China
Xibiao Ye, email: email@example.com
Hua Fu, email: firstname.lastname@example.org
Keywords: non-Hodgkin lymphoma, genetic susceptibility, single nucleotide polymorphism
Received: April 04, 2016 Accepted: December 13, 2016 Published: January 02, 2017
We undertook a hospital-based case-control study to examine the associations between single nucleotide polymorphisms (SNPs) in selected immunoregulatory genes and non-Hodgkin lymphoma (NHL) risk in a Chinese population. One hundred and sixty-nine NHL patients diagnosed according to the World Health Organization (WHO) 2001 standard and 421 controls were recruited. Nine SNPs in three genes (IL-10, IL-1RN, and TNF-α) were selected based on predicted functions and previous study findings. Genetic association analysis was performed using the Cochran-Armitage trend test and multiple logistic regression. Four SNPs were associated with an increased risk of overall NHL: odds ratio per minor allele [ORper-minor-allele] and 95% confidence interval [CI] were 2.64 (1.75-3.98) for IL-10 rs1800893, 2.67 (1.72-4.16) for IL-1RN rs4251961, 1.80 (1.24-2.63) for TNF- α rs1800630, and 1.55 (1.02-2.37) for TNF- α rs2229094. These SNPs were also associated with an increased risk of diffuse large B-cell lymphoma (DLBCL). In addition, another SNP (TNF- α rs1041981) was associated with an increased risk of DLBCL (ORper-minor-allele=1.73, 95% CI 1.14-2.61). The findings provide evidence on the role of these immunoregulatory gene variants in NHL etiology.
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