Oncotarget

Research Papers:

Association of genetic polymorphisms with laryngeal carcinoma prognosis in a Chinese population

Fang Quan, Feipeng Zhang, Yanxia Bai, Long Zhou, Hua Yang, Bin Li, Tianbo Jin, Huajing Li and Yuan Shao _

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Oncotarget. 2017; 8:10255-10263. https://doi.org/10.18632/oncotarget.14381

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Abstract

Fang Quan1,*, Feipeng Zhang1,*, Yanxia Bai1, Long Zhou2, Hua Yang3, Bin Li3, Tianbo Jin3, Huajing Li1, Yuan Shao1

1Department of Otolaryngology & Head Neck, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710061, China

2Sichuan Yanting Middle School, Mianyang, Sichuan, 621600, China

3School of Life Sciences, Northwest University, Xi’an, Shaanxi, 710069, China

*These authors have contributed equally to this work

Correspondence to:

Huajing Li, email: huajinglidoc@163.com

Yuan Shao, email: jiaodashaoyuan@163.com

Keywords: laryngeal carcinoma, single-nucleotide polymorphism, overall survival, hazard ratio

Received: October 20, 2016    Accepted: December 13, 2016    Published: December 30, 2016

ABSTRACT

We analyzed the effects of single-nucleotide polymorphisms (SNPs) on laryngeal carcinoma (LC) risk and overall survival (OS) in 170 Chinese male LC patients followed for 10 years. After assessment of clinical characteristics (age, laryngectomy, neck dissection, tumor differentiation, TNM status), the patients were genotyped for 24 SNPs associated with risk in multiple cancers. LC risk was assessed using log-rank test and Cox proportional hazard models. The median OS time was 48 months. By the follow-up deadline, OS was 41.2%. Kaplan-Meier analysis indicated 1-, 3-, and 5-year survival rates to be 84.7%, 57.2%, and 47.1%, respectively. Five LC clinicopathological characteristics, namely total laryngectomy (TL), low differentiation (LD), T3-T4, N1-N2, and clinical stage III-IV were associated with worse OS (HR: 2.35, p < 0.001; HR: 2.39, p = 0.02; HR: 2.17, p < 0.001; HR: 2.39, p < 0.001; and HR: 3.29, p < 0.001, respectively). Univariate cox regression analysis indicated that four SNPs were associated (p < 0.05) with LC OS in the codominant genetic model compared to patients with the homozygous wild-type genotype: rs10088262 G/A (HR = 1.57), rs1665650 A/G (HR = 0.65); rs3802842 C/C (HR = 2.18), and rs59336 T/A and T/T (HR = 0.61 and 2.61, respectively).


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