Association of genetic polymorphisms with laryngeal carcinoma prognosis in a Chinese population
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Fang Quan1,*, Feipeng Zhang1,*, Yanxia Bai1, Long Zhou2, Hua Yang3, Bin Li3, Tianbo Jin3, Huajing Li1, Yuan Shao1
1Department of Otolaryngology & Head Neck, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710061, China
2Sichuan Yanting Middle School, Mianyang, Sichuan, 621600, China
3School of Life Sciences, Northwest University, Xi’an, Shaanxi, 710069, China
*These authors have contributed equally to this work
Huajing Li, email: [email protected]
Yuan Shao, email: [email protected]
Keywords: laryngeal carcinoma, single-nucleotide polymorphism, overall survival, hazard ratio
Received: October 20, 2016 Accepted: December 13, 2016 Published: December 30, 2016
We analyzed the effects of single-nucleotide polymorphisms (SNPs) on laryngeal carcinoma (LC) risk and overall survival (OS) in 170 Chinese male LC patients followed for 10 years. After assessment of clinical characteristics (age, laryngectomy, neck dissection, tumor differentiation, TNM status), the patients were genotyped for 24 SNPs associated with risk in multiple cancers. LC risk was assessed using log-rank test and Cox proportional hazard models. The median OS time was 48 months. By the follow-up deadline, OS was 41.2%. Kaplan-Meier analysis indicated 1-, 3-, and 5-year survival rates to be 84.7%, 57.2%, and 47.1%, respectively. Five LC clinicopathological characteristics, namely total laryngectomy (TL), low differentiation (LD), T3-T4, N1-N2, and clinical stage III-IV were associated with worse OS (HR: 2.35, p < 0.001; HR: 2.39, p = 0.02; HR: 2.17, p < 0.001; HR: 2.39, p < 0.001; and HR: 3.29, p < 0.001, respectively). Univariate cox regression analysis indicated that four SNPs were associated (p < 0.05) with LC OS in the codominant genetic model compared to patients with the homozygous wild-type genotype: rs10088262 G/A (HR = 1.57), rs1665650 A/G (HR = 0.65); rs3802842 C/C (HR = 2.18), and rs59336 T/A and T/T (HR = 0.61 and 2.61, respectively).
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