Research Papers:

Single nucleotide polymorphisms in ZNRD1-AS1 increase cancer risk in an Asian population

Ping-Yu Wang, Jing-Hua Li, Yue-Mei Liu, Qing Lv, Ning Xie, Han-Han Zhang and Shu-Yang Xie _

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Oncotarget. 2017; 8:10064-10070. https://doi.org/10.18632/oncotarget.14334

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Ping-Yu Wang1,2, Jing-Hua Li2, Yue-Mei Liu1, Qing Lv1, Ning Xie3, Han-Han Zhang1, Shu-Yang Xie1

1Key Laboratory of Tumor Molecular Biology in Binzhou Medical University, Department of Biochemistry and Molecular Biology, Binzhou Medical University, YanTai, ShanDong, 264003, P.R.China

2Department of Epidemiology, Binzhou Medical University, YanTai, ShanDong, 264003, P.R.China

3Department of Chest Surgery, YanTaiShan Hospital, YanTai, ShanDong, 264000, P.R.China

Correspondence to:

Shu-Yang Xie, email: [email protected]

Keywords: ZNRD1-AS1, single nucleotide polymorphism, cancer, meta-analysis, lncRNA

Received: August 12, 2016     Accepted: December 01, 2016     Published: December 28, 2016


Single nucleotide polymorphisms (SNPs) in human zinc ribbon domain containing 1 antisense RNA 1 (ZNRD1-AS1) have been associated with cancer development. In this meta-analysis, we more precisely estimated the associations between three expression quantitative trait loci SNPs in ZNRD1-AS1 (rs3757328, rs6940552, and rs9261204) and cancer susceptibility. The data for three SNPs were extracted from eligible studies, which included 5,293 patients and 5,440 controls. Overall, no significant associations between SNPs in ZNRD1-AS1 (rs3757328, rs6940552, and rs9261204) and cancer risk were observed. However, in further subgroup analyses based on cancer type, we found that the A allele of rs3757328 increased the risk of some cancer in both allele contrast (OR = 1.15, 95% CI = 1.05 – 1.25) and recessive models (OR = 1.79; 95% CI = 1.33 – 2.41). The A allele of rs6940552 and the G allele of rs9261204 also increased the risk of some cancer in an Asian population in allele contrast (OR = 1.17, 95% CI = 1.08 – 1.26, and OR = 1.25, 95% CI = 1.16 – 1.34, respectively) and recessive models (OR = 1.44, 95% CI = 1.18 – 1.77, and OR = 1.49; 95% CI = 1.23 – 1.80, respectively). Thus, rs3757328, rs6940552, and rs9261204 in ZNRD1-AS1 are all associated with increased some cancer risk in an Asian population.

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