Genetic polymorphisms in the telomere length-related gene ACYP2 are associated with the risk of colorectal cancer in a Chinese Han population
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Fang Liu1,2,*, Zhongguo Zhang1,2,*, Yong Zhang3, Yue Chen2, Xiaoyu Yang2, Jibin Li2, Jiaxing Zhao1
1Large-Scale Data Analysis Center of Cancer Precision Medicine, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Dadong District, Shenyang 110042, Liaoning Province, P R China
2Department of Colorectal Cancer Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Dadong District, Shenyang 110042, Liaoning Province, P R China
3Department of Pathology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Dadong District, Shenyang 110042, Liaoning Province, P R China
*These authors have contributed equally to this work
Zhongguo Zhang, email: [email protected]
Keywords: single nucleotide polymorphism (SNP), ACYP2, telomere length, colorectal cancer, association study
Received: October 09, 2016 Accepted: November 24, 2016 Published: December 25, 2016
We investigated the association between single nucleotide polymorphisms (SNPs) in ACYP2, which has been associated with telomere length in several types of cancer, and the risk of CRC in a Chinese Han population. In a case-control study that included 247 cases and 300 healthy controls, 14 SNPs in ACYP2 were selected and genotyped using the Sequenom MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression after adjusting for age and gender. We determined that rs843711 and rs843706 were associated with an increased risk of CRC (rs843711: OR = 1.376, 95% CI = 1.082-1.749, p = 0.009; rs843706: OR = 1.361, 95% CI = 1.069-1.733, p = 0.012). Additionally, rs6713088, rs843645, rs843711, and rs843706 were associated with an increased risk of CRC under additive and recessive models (p < 0.05). Finally, the “TTCTCGCC” and “CG” haplotypes decreased the risk of CRC, while the “AG” haplotype increase the risk of CRC. The association between rs843711 and CRC remained significant after Bonferroni correction for multiple comparisons (p ≤ 0.00036). Our data shed new light on the associations between genetic variants in the ACYP2 gene and CRC susceptibility in a Chinese Han population.
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