Oncotarget

Research Papers:

Abnormal brain functional connectivity leads to impaired mood and cognition in hyperthyroidism: a resting-state functional MRI study

Ling Li, Mengmeng Zhi, Zhenghua Hou, Yuqun Zhang, Yingying Yue and Yonggui Yuan _

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Oncotarget. 2017; 8:6283-6294. https://doi.org/10.18632/oncotarget.14060

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Abstract

Ling Li1, Mengmeng Zhi1, Zhenghua Hou2, Yuqun Zhang2, Yingying Yue2, Yonggui Yuan2,3

1Department of Endocrinology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, China

2Department of Psychosomatics and Psychiatry, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, China

3Neuropsychiatric Institute, Affiliated ZhongDa Hospital, Southeast University, Nanjing, Jiangsu, 210009, China

Correspondence to:

Yonggui Yuan, email: yygylh2000@sina.com

Keywords: hyperthyroidism, degree centrality, functional connectivity, emotion, cognition

Received: October 31, 2016     Accepted: December 13, 2016     Published: December 21, 2016

ABSTRACT

Patients with hyperthyroidism frequently have neuropsychiatric complaints such as lack of concentration, poor memory, depression, anxiety, nervousness, and irritability, suggesting brain dysfunction. However, the underlying process of these symptoms remains unclear. Using resting-state functional magnetic resonance imaging (rs-fMRI), we depicted the altered graph theoretical metric degree centrality (DC) and seed-based resting-state functional connectivity (FC) in 33 hyperthyroid patients relative to 33 healthy controls. The peak points of significantly altered DC between the two groups were defined as the seed regions to calculate FC to the whole brain. Then, partial correlation analyses were performed between abnormal DC, FC and neuropsychological performances, as well as some clinical indexes. The decreased intrinsic functional connectivity in the posterior lobe of cerebellum (PLC) and medial frontal gyrus (MeFG), as well as the abnormal seed-based FC anchored in default mode network (DMN), attention network, visual network and cognitive network in this study, possibly constitutes the latent mechanism for emotional and cognitive changes in hyperthyroidism, including anxiety and impaired processing speed.


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PII: 14060