Oncotarget

Research Papers:

Precise integrin-targeting near-infrared imaging-guided surgical method increases surgical qualification of peritoneal carcinomatosis from gastric cancer in mice

Haidong Cheng, Chongwei Chi, Wenting Shang, Sha Rengaowa, Jianxin Cui, Jinzuo Ye, Shixin Jiang, Yamin Mao, Caoting Zeng, Huiping Huo, Lin Chen and Jie Tian _

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Oncotarget. 2017; 8:6258-6272. https://doi.org/10.18632/oncotarget.14058

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Abstract

Haidong Cheng1,2,3,*, Chongwei Chi3,*, Wenting Shang3,*, Sha Rengaowa4, Jianxin Cui1, Jinzuo Ye3, Shixin Jiang3, Yamin Mao3, Caoting Zeng5, Huiping Huo6, Lin Chen1, Jie Tian3

1Department of General Surgery, The Chinese PLA General Hospital, Beijing, 100853, China

2Department of General Surgery, The First Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010059, China

3Key Laboratory of Molecular Imaging of the Chinese Academy of Sciences, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China

4Department of Basic Medical Science, Inner Mongolia Medical University, Hohhot, 010059, China

5Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China

6Department of Ultrasound, General Hospital of the People’s Liberation Army, Beijing, 100853, China

*These authors contributed equally to this work

Correspondence to:

Jie Tian, email: tian@ieee.org, jie.tian@ia.ac.cn

Lin Chen, email: chenlin301@yeah.net

Keywords: gastric cancer, fluorescence molecular imaging, peritoneal carcinomatosis, integrin

Received: July 18, 2016     Accepted: December 12, 2016     Published: December 21, 2016

ABSTRACT

Peritoneal carcinomatosis from gastric cancer represents a common recurrent gastric cancer that seriously affects the survival, prognosis, and quality of life of patients at its advanced stage. In recent years, complete cytoreduction surgery in combination with hyperthermic intraperitoneal chemotherapy has been demonstrated to improve the survival and prognosis of patients with malignant tumors including peritoneal carcinomatosis from gastric cancer. Establishing viable methods of accurately assessing the tumor burden in patients with peritoneal carcinoma and correctly selecting suitable patients in order to improve cytoreduction surgical outcomes and reduce the risk of postoperative complications has become a challenge in the field of peritoneal carcinoma research. Here, we investigated peritoneal carcinomatosis from gastric cancer in a mouse model by using our self-developed surgical navigation system that combines optical molecular imaging with an integrin-targeting Arg-Gly-Asp-indocyanine green (RGD-ICG) molecular probe. The results showed that our diagnostic method could achieve a sensitivity and specificity of up to 93.93% and 100%, respectively, with a diagnostic index (DI) of 193.93% and diagnostic accuracy rate of 93.93%.Furthermore, the minimum tumor diameter measured during the surgery was 1.8 mm and the operative time was shortened by 3.26-fold when compared with the conventionally-treated control group. Therefore, our surgical navigation system that combines optical molecular imaging with an RGD-ICG molecular probe, could improve the diagnostic accuracy rate for peritoneal carcinomatosis from gastric cancer, shorten the operative time, and improve the quality of the cytoreduction surgery for peritoneal carcinomatosis from gastric cancer, thus providing a solid foundation for its future clinical development and application.


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