MicroRNAs as regulators and mediators of forkhead box transcription factors function in human cancers

Chen Li, Kai Zhang, Jing Chen, Longbang Chen, Rui Wang _ and Xiaoyuan Chu

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Oncotarget. 2017; 8:12433-12450. https://doi.org/10.18632/oncotarget.14015

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Chen Li1, Kai Zhang1, Jing Chen1, Longbang Chen1, Rui Wang1 and Xiaoyuan Chu1

1 Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu, PR China

Correspondence to:

Rui Wang, email:

Xiaoyuan Chu, email:

Keywords: microRNA; forkhead box transcription factor; cancer; post-transcriptional regulation

Received: July 28, 2016 Accepted: December 07, 2016 Published: December 16, 2016


Evidence has shown that microRNAs are widely implicated as indispensable components of tumor suppressive and oncogenic pathways in human cancers. Thus, identification of microRNA targets and their relevant pathways will contribute to the development of microRNA-based therapeutics. The forkhead box transcription factors regulate numerous processes including cell cycle progression, metabolism, metastasis and angiogenesis, thereby facilitating tumor initiation and progression. A complex network of protein and non-coding RNAs mediates the expression and activity of forkhead box transcription factors. In this review, we summarize the current knowledge and concepts concerning the involvement of microRNAs and forkhead box transcription factors and describe the roles of microRNAs-forkhead box axis in various disease states including tumor initiation and progression. Additionally, we describe some of the technical challenges in the use of the microRNA-forkhead box signaling pathway in cancer treatment.

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