Research Papers:

Clinicopathological and prognostic significance of COX-2 immunohistochemical expression in breast cancer: a meta-analysis

Feng Xu, Mengxin Li, Chao Zhang, Jianxiu Cui, Jun Liu, Jie Li and Hongchuan Jiang _

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Oncotarget. 2017; 8:6003-6012. https://doi.org/10.18632/oncotarget.13990

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Feng Xu1,*, Mengxin Li1, Chao Zhang1, Jianxiu Cui1, Jun Liu1, Jie Li1, Hongchuan Jiang1

1Department of Breast Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China, 100020

*Co-first author

Correspondence to:

Hongchuan Jiang, email: [email protected]

Keywords: breast cancer, COX-2, prognosis, meta-analysis

Received: July 04, 2016     Accepted: December 12, 2016     Published: December 16, 2016


The prognostic significance of COX-2 in patients with breast cancer remains controversial. The aims of our meta-analysis are to evaluate its association with clinicopathological characteristics and prognostic value in patients with breast cancer. PubMed, EMBASE, Web of Science, the Ovid Database and Grey literature were systematically searched up to May 2016. Twenty-one studies including 6739 patients with breast cancer were analyzed. The meta-analysis indicated that the incidence difference of COX-2 expression was significant when comparing the lymph node positive group to negative group (OR = 1.76, 95% CI [1.30, 2.39]) and the tumor size ≥ 2cm group to the tumor size < 2cm group (OR = 1.71, 95% CI [1.22, 2.39]). None of other clinicopathological parameters such as the ER status, PR status, HER2 status and the vascular invasion status were associated with COX-2 overexpression. The detection of COX-2 was significantly correlated with the disease-free survival (DFS) of patients (HR = 1.58, 95% CI [1.23, 2.03]) and the overall survival (OS) of patients (HR = 1.51, 95% CI [1.31, 1.72]). Our meta-analysis demonstrates that the presence of high levels of COX-2 is associated with poor prognosis for breast cancer patients and predicts bigger tumor size and lymph node metastasis.

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