Noninvasive amide proton transfer magnetic resonance imaging in evaluating the grading and cellularity of gliomas
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Yan Bai1,*, Yusong Lin2,*, Wei Zhang3, Lingfei Kong4, Lifu Wang4, Panli Zuo5, Ignacio Vallines6, Benjamin Schmitt7, Jie Tian8, Xiaolei Song9, Jinyuan Zhou9 and Meiyun Wang1
1 Department of Radiology, Zhengzhou University People’s Hospital & Henan Provincial People’s Hospital, Zhengzhou, Henan, China
2 Cooperative Innovation Center of Internet Healthcare & School of Software and Applied Technology, Zhengzhou University, Zhengzhou, Henan, China
3 Department of Radiology, Ren Ji Hospital of Shanghai Jiao Tong University, Shanghai, China
4 Department of Pathology, Zhengzhou University People’s Hospital & Henan Provincial People’s Hospital, Zhengzhou, Henan, China
5 MR Collaborations NE Asia, Siemens Healthcare China, Beijing, China
6 MR Collaborations NE Asia, Siemens Healthcare China, Shanghai, China
7 Imaging & Therapy Systems Division, Siemens Healthcare Australia, Brisbane, Australia
8 Institute of Automation, Chinese Academy of Sciences, Beijing, China
9 Department of Radiology, Johns Hopkins University, Baltimore, MD, USA
* These authors have contributed equally to this work
Meiyun Wang, email:
Keywords: amide proton transfer, glioma, grading, Ki-67, magnetic resonance imaging
Received: July 04, 2016 Accepted: December 12, 2016 Published: December 15, 2016
Using noninvasive magnetic resonance imaging techniques to accurately evaluate the grading and cellularity of gliomas is beneficial for improving the patient outcomes. Amide proton transfer imaging is a noninvasive molecular magnetic resonance imaging technique based on chemical exchange saturation transfer mechanism that detects endogenous mobile proteins and peptides in biological tissues. Between August 2012 and November 2015, a total number of 44 patients with pathologically proven gliomas were included in this study. We compared the capability of amide proton transfer magnetic resonance imaging with that of noninvasive diffusion-weighted imaging and noninvasive 3-dimensional pseudo-continuous arterial spin imaging in evaluating the grading and cellularity of gliomas. Our results reveal that amide proton transfer magnetic resonance imaging is a superior imaging technique to diffusion-weighted imaging and 3-dimensional pseudo-continuous arterial spin imaging in the grading of gliomas. In addition, our results showed that the Ki-67 index correlated better with the amide proton transfer-weighted signal intensity than with the apparent diffusion coefficient value or the cerebral blood flow value in the gliomas. Amide proton transfer magnetic resonance imaging is a promising method for predicting the grading and cellularity of gliomas.
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