Oncotarget

Research Papers:

Noninvasive amide proton transfer magnetic resonance imaging in evaluating the grading and cellularity of gliomas

Yan Bai, Yusong Lin, Wei Zhang, Lingfei Kong, Lifu Wang, Panli Zuo, Ignacio Vallines, Benjamin Schmitt, Jie Tian, Xiaolei Song, Jinyuan Zhou and Meiyun Wang _

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Oncotarget. 2017; 8:5834-5842. https://doi.org/10.18632/oncotarget.13970

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Abstract

Yan Bai1,*, Yusong Lin2,*, Wei Zhang3, Lingfei Kong4, Lifu Wang4, Panli Zuo5, Ignacio Vallines6, Benjamin Schmitt7, Jie Tian8, Xiaolei Song9, Jinyuan Zhou9 and Meiyun Wang1

1 Department of Radiology, Zhengzhou University People’s Hospital & Henan Provincial People’s Hospital, Zhengzhou, Henan, China

2 Cooperative Innovation Center of Internet Healthcare & School of Software and Applied Technology, Zhengzhou University, Zhengzhou, Henan, China

3 Department of Radiology, Ren Ji Hospital of Shanghai Jiao Tong University, Shanghai, China

4 Department of Pathology, Zhengzhou University People’s Hospital & Henan Provincial People’s Hospital, Zhengzhou, Henan, China

5 MR Collaborations NE Asia, Siemens Healthcare China, Beijing, China

6 MR Collaborations NE Asia, Siemens Healthcare China, Shanghai, China

7 Imaging & Therapy Systems Division, Siemens Healthcare Australia, Brisbane, Australia

8 Institute of Automation, Chinese Academy of Sciences, Beijing, China

9 Department of Radiology, Johns Hopkins University, Baltimore, MD, USA

* These authors have contributed equally to this work

Correspondence to:

Meiyun Wang, email:

Keywords: amide proton transfer, glioma, grading, Ki-67, magnetic resonance imaging

Received: July 04, 2016 Accepted: December 12, 2016 Published: December 15, 2016

Abstract

Using noninvasive magnetic resonance imaging techniques to accurately evaluate the grading and cellularity of gliomas is beneficial for improving the patient outcomes. Amide proton transfer imaging is a noninvasive molecular magnetic resonance imaging technique based on chemical exchange saturation transfer mechanism that detects endogenous mobile proteins and peptides in biological tissues. Between August 2012 and November 2015, a total number of 44 patients with pathologically proven gliomas were included in this study. We compared the capability of amide proton transfer magnetic resonance imaging with that of noninvasive diffusion-weighted imaging and noninvasive 3-dimensional pseudo-continuous arterial spin imaging in evaluating the grading and cellularity of gliomas. Our results reveal that amide proton transfer magnetic resonance imaging is a superior imaging technique to diffusion-weighted imaging and 3-dimensional pseudo-continuous arterial spin imaging in the grading of gliomas. In addition, our results showed that the Ki-67 index correlated better with the amide proton transfer-weighted signal intensity than with the apparent diffusion coefficient value or the cerebral blood flow value in the gliomas. Amide proton transfer magnetic resonance imaging is a promising method for predicting the grading and cellularity of gliomas.


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