Research Papers:

CT-guided percutaneous laser ablation of metastatic lung cancer: three cases report and literature review

Qiyu Zhao, Guo Tian, Fen Chen, Liyun Zhong and Tian’an Jiang _

PDF  |  HTML  |  Supplementary Files  |  How to cite

Oncotarget. 2017; 8:2187-2196. https://doi.org/10.18632/oncotarget.13901

Metrics: PDF 1892 views  |   HTML 2529 views  |   ?  


Qiyu Zhao1, Guo Tian2, Fen Chen3, Liyun Zhong1 and Tian’an Jiang1

1 Department of Ultrasonography, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou China

2 State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

3 Department of Hepatobiliary Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

Correspondence to:

Tian’an Jiang, email:

Keywords: laser ablation; CT-guided; computed tomography; lung; lung cancer

Received: September 02, 2016 Accepted: November 22, 2016 Published: December 10, 2016


Objective: To report the efficacy and safety of CT-guided percutaneous laser ablation (PLA) for metastatic lung tumors.

Methods: Three cases of metastatic lung cancer underwent CT-guided PLA, and we searched for previously published articles on the minimally invasive CT-guided RFA or MWA for lung tumors in recent five years.

Results: With the guidance of CT, all lesions had good prognosis under laser ablation. Case 1 suffering from severe pulmonary dysfunction and diffuse pulmonary bullae, had small pneumothorax. CT scan obtained four months following the ablation showed two lesions had complete responses and one partial response. Case 2 had successful complete response with absent lung mass, and also had a good postoperative condition without any discomfort in the two-month follow-up. Case 3 showed partial response and improved greatly after five months. 962 cases (mean age of 45.7 years, 62.2% male) of 1297 lung tumors with detailed information were identified from 27 articles. Of these cases, the minority manifested complications such as pneumothorax, hemoptysis, hemothorax, pneumonia, pain and fever.

Conclusions: Percutaneous CT-guided PLA could be a safe and promising minimally invasive treatment for patients with primary lung cancer or unresectable pulmonary metastases, especially multineedle PLA in large tumors, which still needs more large-scale prospective studies to convince this method in the future.

Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 13901