High expression of Snail and NF-κB predicts poor survival in Chinese hepatocellular carcinoma patients
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Min Zhang1,2, Xin Dong3, Dengcai Zhang4, Xiaojie Chen2, Xinyu Zhu2
1Department of Pathology, Department of Scientific Research Gansu Provincial Hospital, Lanzhou 730000, P.R. China
2Department of Scientific Research, Gansu Provincial Hospital, Lanzhou 730000, P.R. China
3The Third Hospital of Gansu Province, Lanzhou 730020, P.R. China
4Department of Pathology, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou 730050, P.R. China
Min Zhang, email: [email protected]
Keywords: hepatocellular carcinoma, Snail, NF-κB, survival, Chinese population
Received: September 30, 2016 Accepted: December 01, 2016 Published: December 10, 2016
In this study, we explored the roles of Snail and NF-κB in hepatocellular carcinoma (HCC). Samples of HCC tumor tissue were collected from 83 Chinese HCC patients. Snail and NF-κB expression was then examined based on immunohistochemical staining, and the relations between Snail and NF-κB expression and the clinical characteristics of the patients were assessed using Cox model analysis. Snail and NF-κB were both expressed in HCC tissue, and their levels were strongly correlated. In addition, levels of both Snail and NF-κB expression were negatively related to tumor differentiation, which was an independent factor predictive of survival in HCC patients. Snail and NF-κB may thus be useful markers of tumor differentiation and survival in HCC, and may also be useful for guiding treatment and exploring molecular mechanisms.
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