Oncotarget

Research Papers:

Prospective study on factors affecting the prognosis of oral cancer in a Chinese population

Fengqiong Liu, Fa Chen, Jiangfeng Huang, Lingjun Yan, Fangping Liu, Junfeng Wu, Yu Qiu, Xiaoyan Zheng, Rongzhao Zhang, Lisong Lin and Baochang He _

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Oncotarget. 2017; 8:4352-4359. https://doi.org/10.18632/oncotarget.13842

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Abstract

Fengqiong Liu1, Fa Chen1, Jiangfeng Huang1, Lingjun Yan1, Fangping Liu1, Junfeng Wu1, Yu Qiu2, Xiaoyan Zheng2, Rongzhao Zhang1, Lisong Lin2, Baochang He1

1Department of Epidemiology and Health Statistic, Fujian Provincial Key Laboratory of Environment factors and Cancer, School of Public Health, Fujian Medical University, Fujian, China

2Department of Stomatology, The First Affiliated Hospital of Fujian Medical University, Fujian, China

Correspondence to:

Baochang He, email: hbc517@163.com

Lisong Lin, email: Dr_lsling@126.com

Keywords: oral cancer, prognosis, BMI, chemotherapy, radiotherapy

Received: August 01, 2016     Accepted: December 01, 2016     Published: December 09, 2016

ABSTRACT

This study was performed to identify the factors affecting prognosis of oral cancer patients. 1240 pathologically confirmed oral cancer patients were included. The sociodemographic and clinical characteristics of all patients were collected. Univariate and multivariate Cox proportional hazards models were used to assess potential prognostic factors for survival. 1240 oral cancer patients were followed up for 49235.00 person months, and the 5-year overall survival rate was 64.38%. Both univariate and multivariate Cox regression analysis indicated that Body Mass Index < 18.5 kg/m2 (vs 18.5–23.9 kg/m2), age ≥ 55 years (vs < 55 years), clinical stages of II-IV (vs stage I), and poor differentiation (vs well differentiation) were associated with worse survival of oral cancer patients. While surgery (vs non-surgery) and origin of urban area (vs rural area) were protective factors. However, no significant association was found between adjuvant therapy and survival in oral cancer patients.


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