Research Papers:

Association between FGFR2 (rs2981582, rs2420946 and rs2981578) polymorphism and breast cancer susceptibility: a meta-analysis

Yafei Zhang, Xianling Zeng, Pengdi Liu, Ruofeng Hong, Hongwei Lu, Hong Ji, Le Lu and Yiming Li _

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Oncotarget. 2017; 8:3454-3470. https://doi.org/10.18632/oncotarget.13839

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Yafei Zhang1, Xianling Zeng2, Pengdi Liu1, Ruofeng Hong1, Hongwei Lu1, Hong Ji1, Le Lu1, Yiming Li1

1Department of General Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China

2Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an, Shaanxi 710061, China

Correspondence to:

Yiming Li, email: [email protected]

Keywords: breast cancer, FGFR2, polymorphism

Received: August 08, 2016     Accepted: November 22, 2016     Published: December 09, 2016


The association between fibroblast growth factor receptor 2 (FGFR2) polymorphism and breast cancer (BC) susceptibility remains inconclusive. The purpose of this systematic review was to evaluate the relationship between FGFR2 (rs2981582, rs2420946 and rs2981578) polymorphism and BC risk. PubMed, Web of science and the Cochrane Library databases were searched before October 11, 2015 to identify relevant studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the strength of associations. Sensitivity and subgroup analyses were conducted. Thirty-five studies published from 2007 to 2015 were included in this meta-analysis. The pooled results showed that there was significant association between all the 3 variants and BC risk in any genetic model. Subgroup analysis was performed on rs2981582 and rs2420946 by ethnicity and Source of controls, the effects remained in Asians, Caucasians, population-based and hospital-based groups. We did not carryout subgroup analysis on rs2981578 for the variant included only 3 articles. This meta-analysis of case-control studies provides strong evidence that FGFR2 (rs2981582, rs2420946 and rs2981578) polymorphisms were significantly associated with the BC risk. For rs2981582 and rs2420946, the association remained significant in Asians, Caucasians, general populations and hospital populations. However, further large scale multicenter epidemiological studies are warranted to confirm this finding and the molecular mechanism for the association need to be elucidated further.

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