Clinical Research Papers:

Neuroendocrine tumors of colon and rectum: validation of clinical and prognostic values of the World Health Organization 2010 grading classifications and European Neuroendocrine Tumor Society staging systems

Chaoyong Shen _, Yuan Yin, Huijiao Chen, Sumin Tang, Xiaonan Yin, Zongguang Zhou, Bo Zhang and Zhixin Chen

PDF  |  HTML  |  How to cite

Oncotarget. 2017; 8:22123-22134. https://doi.org/10.18632/oncotarget.13641

Metrics: PDF 1985 views  |   HTML 2196 views  |   ?  


Chaoyong Shen1,*, Yuan Yin1,*, Huijiao Chen2, Sumin Tang1, Xiaonan Yin1, Zongguang Zhou1,3, Bo Zhang1, Zhixin Chen1

1Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China

2Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China

3Institute of Digestive Surgery and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China

*These authors have contributed equally to this work

Correspondence to:

Zongguang Zhou, email: [email protected]

Bo Zhang, email: [email protected]

Keywords: neuroendocrine tumors, colorectal, prognosis, WHO classifications, ENETS TNM systems

Received: August 23, 2016     Accepted: November 08, 2016     Published: November 26, 2016


Background/Aims: This study evaluated and compared the clinical and prognostic values of the grading criteria used by the World Health Organization (WHO) and the European Neuroendocrine Tumors Society (ENETS). Moreover, this work assessed the current best prognostic model for colorectal neuroendocrine tumors (CRNETs).

Results: The 2010 WHO classifications and the ENETS systems can both stratify the patients into prognostic groups, although the 2010 WHO criteria is more applicable to CRNET patients. Along with tumor location, the 2010 WHO criteria are important independent prognostic parameters for CRNETs in both univariate and multivariate analyses through Cox regression (P<0.05).

Methods: Data from 192 consecutive patients histopathologically diagnosed with CRNETs and had undergone surgical resection from January 2009 to May 2016 in a single center were retrospectively analyzed.

Conclusions: Findings suggest that the WHO classifications are superior over the ENETS classification system in predicting the prognosis of CRNETs. Additionally, the WHO classifications can be widely used in clinical practice.

Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 13641