Oncotarget

Clinical Research Papers:

Impact of epidemiological characteristics of supratentorial gliomas in adults brought about by the 2016 world health organization classification of tumors of the central nervous system

Haihui Jiang _, Yong Cui, Junmei Wang and Song Lin

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Oncotarget. 2017; 8:20354-20361. https://doi.org/10.18632/oncotarget.13555

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Abstract

Haihui Jiang1,*, Yong Cui2,3,4,*, Junmei Wang5, Song Lin2,3,4

1Department of Neurosurgery, First Hospital of Tsinghua University, Beijing, China

2Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

3China National Clinical Research Center for Neurological Diseases, Beijing, China

4Beijing Institute for Brain Disorders and Beijing Key Laboratory of Brain Tumor, Beijing, China

5Department of Pathology, Beijing Neurosurgical Institute, Beijing, China

*These authors have contributed equally to this work

Correspondence to:

Song Lin, email: [email protected]

Keywords: gliomas, classification, epidemiology, impact

Received: July 27, 2016     Accepted: November 07, 2016     Published: November 24, 2016

ABSTRACT

The latest World Health Organization (WHO) classification of tumors of the central nervous system (CNS) integrates both histological and molecular features in the definition of diagnostic entities. This new approach enrolls novel entities of gliomas. In this study, we aimed to reveal the epidemiological characteristics, including age at diagnosis, gender ratio, tumor distribution and survival, of these new entities. We retrospectively reclassified 1210 glioma samples according to the 2016 CNS WHO diagnostic criteria. In our cohort, glioblastoma multiforme (GBM) with wildtype isocitrate dehydrogenase (IDH) was the most common malignant tumor in the brain. Almost all gliomas were more prevalent in males, especially in the cluster of WHO grade III gliomas and IDH-wildtype GBM. Age at diagnosis was directly proportional to tumor grade. With respect to the distribution by histology, we found that gliomas concurrent with IDH-mutant and 1p/19q-codeleted or with single IDH-mutant were mainly distributed in frontal lobe, while those with IDH-wildtype were dominant in temporal lobe. Lesions located in insular lobe were more likely to be IDH-mutant astrocytoma. In summary, our results elucidated the epidemiological characteristics as well as the regional constituents of these new gliomas entities, which could bring insights into tumorigenesis and personalized treatment of Chinese glioma population.


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