Oncotarget

Research Papers:

Sesamin inhibits IL-1β-stimulated inflammatory response in human osteoarthritis chondrocytes by activating Nrf2 signaling pathway

Pengyu Kong, Guanghua Chen, Anlong Jiang, Yufu Wang, Chengchao Song, Jinpeng Zhuang, Chunyang Xi, Guangxi Wang, Ye Ji and Jinglong Yan _

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Oncotarget. 2016; 7:83720-83726. https://doi.org/10.18632/oncotarget.13360

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Abstract

Pengyu Kong1, Guanghua Chen1, Anlong Jiang1, Yufu Wang1, Chengchao Song1, Jinpeng Zhuang1, Chunyang Xi1, Guangxi Wang1, Ye Ji1, Jinglong Yan1

1Department of Orthopedics Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, China

Correspondence to:

Jinglong Yan, email: hrbmuyjl@163.com

Ye Ji, email: yejilb@163.com

Keywords: sesamin, osteoarthritis chondrocyte, IL-1β, NF-κB, Nrf2

Received: September 12, 2016     Accepted: October 14, 2016     Published: November 15, 2016

ABSTRACT

Sesamin, a bioactive component extracted from sesame, has been reported to exert anti-inflammatory and anti-oxidant effects. In this study, we evaluated the anti-inflammatory effects of sesamin on IL-1β-stimulated human osteoarthritis chondrocytes and investigated the possible mechanism. Results demonstrated that sesamin treatment significantly inhibited PGE2 and NO production induced by IL-1β. Sesamin inhibited MMP1, MMP3, and MMP13 production in IL-1β-stimulated chondrocytes. Sesamin also inhibited IL-1β-induced phosphorylation of NF-κB p65 and IκBα. Meanwhile, sesamin was found to up-regulate the expression of Nrf2 and HO-1. However, Nrf2 siRNA reversed the anti-inflammatory effects of sesamin. In conclusion, our results suggested that sesamin showed anti-inflammatory effects in IL-1β-stimulated chondrocytes by activating Nrf2 signaling pathway.


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