Research Papers:

An early-screening biomarker of endometrial carcinoma: NGAL is associated with epithelio-mesenchymal transition

Ting Li, Li Yu, Jia Wen, Qinping Liao and Zhaohui Liu _

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Oncotarget. 2016; 7:86064-86074. https://doi.org/10.18632/oncotarget.13340

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Ting Li1, Li Yu1, Jia Wen2, Qinping Liao2,*, Zhaohui Liu1,*

1Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China

2Department of Obstetrics and Gynecology, Tsinghua Changgung Hospital, Beijing, China

*These authors contributed equally to this work

Correspondence to:

Qinping Liao, email: [email protected]

Zhaohui Liu, email: 23662161 @qq.com

Keywords: neutrophil gelatinase-associated lipocalin, endometrial cancer, epithelio-mesenchymal transition, epidermal growth Factor

Received: July 15, 2016     Accepted: November 07, 2016     Published: November 14, 2016


neutrophilgelatinase-associated lipocalin is currently one of the most interesting and enigmatic proteins involved in the development of malignancies. In this study, we found that the expression of neutrophilgelatinase-associated lipocalin was up-regulated in endometrial cancer tissues and cell lines, significantly increased in early-grade ones, suggesting it may serve as a biomarker for early-stage screening for endometrial carcinoma. Moreover, neutrophilgelatinase-associated lipocalin was up-regulated in Ishikawa cells under going epithelio-mesenchymal transition induced by epidermal growth factor (5 ng/ml). Up-regulation of neutrophilgelatinase-associated lipocalin may correlate with the down-regulation of E-cadherin expression, up-regulation of Vimentin expression, enhanced cell migration, invasion and proliferation, which are the typical hallmarks of epithelio-mesenchymal transition processes. neutrophilgelatinase-associated lipocalin may play a dual role during tumorigenetic and developmental processes of endometrial carcinoma. These results suggested neutrophilgelatinase-associated lipocalin to be a potential molecular target in the early diagnosis and treatment of endometrial carcinoma. Further studies are warranted to clarify the molecular mechanisms behind the expression and function of neutrophilgelatinase-associated lipocalin and epithelio-mesenchymal transition.

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