Research Papers:

Association of serum 25-hydroxyvitamin D status with bone mineral density in 0-7 year old children

Yanrong Fu, Youfang Hu, Zhenying Qin, Yan Zhao, Zi Yang, Yinfang Li, Guanyu Liang2, Heyun Lv, Hong Hong, Yuan Song, Yarong Wei, Hongni Yue, Wen Zheng, Guoqin Liu, Yufei Ni, Mei Zhu, Aiping Wu, Juhua Yan, Chenbo Ji, Xirong Guo, Juan Wen and Rui Qin _

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Oncotarget. 2016; 7:80811-80819. https://doi.org/10.18632/oncotarget.13097

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Yanrong Fu1,2,3,*, Youfang Hu2,*, Zhenying Qin2, Yan Zhao2, Zi Yang2, Yinfang Li4, Guanyu Liang2, Heyun Lv5, Hong Hong6, Yuan Song7, Yarong Wei8, Hongni Yue9, Wen Zheng10, Guoqin Liu11, Yufei Ni12, Mei Zhu13, Aiping Wu14, Juhua Yan15, Chenbo Ji3, Xirong Guo3, Juan Wen3, Rui Qin2

1Department of Child Health Care, the Second Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, 210011, China

2Department of Child Health Care, Jiangsu Women and Children Health Hospital, Women and Child Branch Hospital of Jiangsu Province Hospital, the First Affiliated Hospital with Nanjing Medical University, Nanjing, 210036, China

3Nanjing Maternity and Child Health Care Institute, Nanjing Maternity and Child Health Care Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, 210029, China

4Department of Pediatrics, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China

5Department of Child Health Care, Jiangning Maternity and Child Health Care Institute, Nanjing, 211100, China

6Department of Child Health Care, Drum Tower Maternity and Child Health Care Institute, Nanjing, 210009, China

7Department of Child Health Care, Suzhou Municipal Hospital, Suzhou, 215000, China

8Department of Child Health Care, Wuxi Maternity and Child Health Care Hospital, Wuxi, 214000, China

9Department of Child Health Care, Huai’an Maternity and Child Health Care Hospital, Huai’an, 223001, China

10Department of Child Health Care, Yancheng Maternity and Child Health Care Institute, Yancheng, 224000, China

11Department of Child Health Care, Dafeng Maternity and Child Health Care Hospital, Dafeng, 224100, China

12Department of Child Health Care, Nantong Maternity and Child Health Care Hospital, Nantong, 226000, China

13Department of Child Health Care, Xuzhou Children's Hospital, Xuzhou, 221000, China

14Department of Child Health Care, Xinghua Maternity and Child Health Care Hospital, Xinghua, 225700, China

15Department of Child Health Care, Kunshan Maternity and Child Health Care Institute, Kunshan, 215300, China

*These authors contributed equally to this work

Correspondence to:

Rui Qin, email: [email protected]

Juan Wen, email: [email protected]

Keywords: serum 25-hydoxyvitamin D, bone mineral density, 0-7 year old children

Received: September 14, 2016     Accepted: October 28, 2016     Published: November 04, 2016


Objective: To describe the status of serum 25-hydoxyvitamin D [25(OH)D] concentrations and identify the relationship between 25(OH)D and bone mineral density (BMD). In an effort to explore the appropriate definition of vitamin D (VD) deficiency in 0–7 year old children.

Results: The median serum 25(OH)D concentrations was 62.9 nmol/L and 28.9% of the children had a low 25(OH)D (< 50 nmol/L). And a linear relation between 25(OH)D concentrations and BMD was surveyed (r = 0.144 , P < 0.001). After adjusting for the confounders, serum 25(OH)D was positively associated with BMD (β = 172.0, 95%CI = 142.8–201.2, P < 0.001), and low 25(OH)D (< 75 nmol/L) had a high stake for low BMD (OR = 1.424, 95%CI = 1.145–1.769, P = 0.001). Additionally, there was a nonlinear relation between 25(OH)D and low BMD, and a critical value for 25(OH)D of 75 nmol/L appeared for low BMD. The prevalence of low BMD was 14.1% in children with 25(OH)D ≥ 75 nmol/L, much lower than that of the concentrations between 50–75 nmol/L and < 50 nmol/L.

Materials and Methods: A total of 4,846 children 0–7 years old were recruited in Jiangsu Province, China. BMD and serum 25(OH)D concentrations were determined by quantitative ultrasound and enzyme-linked immunosorbent assay, respectively. Linear regression and logistic regression analyses were used to assess the association of 25(OH)D concentrations with BMD.

Conclusions: Serum 25(OH)D concentrations was related with BMD and 25(OH)D concentrations < 75 nmol/L might be a more appropriate definition of VD deficiency in 0–7 year old children.

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