Research Papers:

Meta-analysis of laparoscopic versus open liver resection for colorectal liver metastases

Zhi-qiang Tian, Xiao-fang Su, Zhi-yong Lin, Meng-chao Wu, Li-xin Wei and Jia He _

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Oncotarget. 2016; 7:84544-84555. https://doi.org/10.18632/oncotarget.13026

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Zhi-qiang Tian1,2,*, Xiao-fang Su3,*, Zhi-yong Lin4,*, Meng-chao Wu1, Li-xin Wei1, Jia He4

1Tumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai 200438, China

2Department of General Surgery, Wuxi People’s Hospital Affiliated Nanjing Medical University, Wuxi, Jiangsu 214023, China

3Department of Rehabilitation and Physiotherapy Medicine, Wuxi Taihu Hospital (101 Hospital of Chinese People’s Liberation Army), Wuxi, Jiangsu 214044, China

4Department of Health Statistics, The Second Military Medical University, Shanghai 200433, China

*These authors have contributed equally to this work

Correspondence to:

Li-xin Wei, email: [email protected]

Jia He, email: [email protected]

Keywords: colorectal liver metastases, laparoscopic liver resection, open liver resection, meta-analysis

Received: August 08, 2016     Accepted: October 24, 2016     Published: November 02, 2016


Background: To compare surgical and oncological outcomes of laparoscopic versus open liver resection for colorectal liver metastases.

Results: A total of 14 retrospective studies with 1679 colorectal liver metastases patients were analyzed: 683 patients treated with laparoscopic liver resection and 996 patients with open liver resection. With respect to surgical outcomes, laparoscopic compared with open liver resection was associated with lower blood loss (MD, -216.7, 95% CI, -309.4 to -124.1; P < 0.00001), less requiring blood transfusion (OR, 0.36; 95% CI, 0.23 to 0.55; P < 0.00001), lower postoperative complication morbidity (OR, 0.61; 95% CI, 0.47 to 0.80; P = 0.003), and shorter hospitalization time (MD, -3.85, 95% CI, -5.00 to -2.71; P < 0.00001). However, operation time and postoperative mortality were no significant difference between the two approaches. With respect to oncological outcomes, laparoscopic liver resection group was prone to lower recurrence rate (OR, 0.78; 95% CI, 0.61−0.99; P = 0.04), but surgical margins R0, overall survival and disease-free survival were no significant difference.

Materials and Methods: We performed a systematic search in MEDLINE, EMBASE, and CENTRAL for all relevant studies. All statistical analysis was performed using Review Manager version 5.3. Dichotomous data were calculated by odds ratio (OR) and continuous data were calculated by mean difference (MD) with 95% confidence intervals (CI).

Conclusions: Laparoscopic and open liver resection for colorectal liver metastases have the same effect on oncological outcomes, but laparoscopic liver resection achieves better surgical outcomes.

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