Oncotarget

Research Papers:

Marital status is an independent prognostic factor for tracheal cancer patients: an analysis of the SEER database

Mu Li, Chen-Yang Dai, Yu-Ning Wang, Tao Chen, Long Wang, Ping Yang, Dong Xie, Rui Mao and Chang Chen _

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Oncotarget. 2016; 7:77152-77162. https://doi.org/10.18632/oncotarget.12809

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Abstract

Mu Li1, Chen-Yang Dai1, Yu-Ning Wang2, Tao Chen1, Long Wang1, Ping Yang3, Dong Xie1, Rui Mao1, Chang Chen1

1Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China

2Deloitte and Touche Financial Advisory Services Limited, Shanghai, People’s Republic of China

3Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA

Correspondence to:

Chang Chen, email: [email protected]

Keywords: tracheal cancer, marital status, socio-economics, SEER, survival analysis

Received: June 07, 2016     Accepted: October 12, 2016     Published: October 21, 2016

ABSTRACT

Background: Although marital status is an independent prognostic factor in many cancers, its prognostic impact on tracheal cancer has not yet been determined. The goal of this study was to examine the relationship between marital status and survival in patients with tracheal cancer.

Results: Compared with unmarried patients (42.67%), married patients (57.33%) had better 5-year OS (25.64% vs. 35.89%, p = 0.009) and 5-year TCSS (44.58% vs. 58.75%, p = 0.004). Results of multivariate analysis indicated that marital status is an independent prognostic factor, with married patients showing better OS (hazard ratio [HR] = 0.78, 95% confidence interval [CI] 0.64–0.95, p = 0.015) and TCSS (HR = 0.70, 95% CI 0.54–0.91, p = 0.008). In addition, subgroup analysis suggested that marital status plays a more important role in the TCSS of patients with non-low-grade malignant tumors (HR = 0.71, 95% CI 0.53–0.93, p = 0.015).

Methods: We extracted 600 cases from the Surveillance, Epidemiology, and End Results (SEER) database. Variables were compared by Pearson chi-squared test, t-test, log-rank test, and multivariate Cox regression analysis. Overall survival (OS) and tracheal cancer-specific survival (TCSS) were compared between subgroups with different pathologic features and tumor stages.

Conclusions: Marital status is an independent prognostic factor for survival in patients with tracheal cancer. For that reason, additional social support may be needed for unmarried patients, especially those with non-low-grade malignant tumors.


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