Meta-analysis of the correlation between selenium and incidence of hepatocellular carcinoma

Ziwei Zhang; Mingyu Bi; Qi Liu; Jie Yang; Shiwen Xu

doi:10.18632/oncotarget.12804

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Meta-analysis of the correlation between selenium and incidence of hepatocellular carcinoma

Ziwei Zhang, Mingyu Bi, Qi Liu, Jie Yang and Shiwen Xu _

PDF | HTML | How to cite

Oncotarget. 2016; 7:77110-77116. https://doi.org/10.18632/oncotarget.12804

Metrics: PDF 2225 views | HTML 2236 views | ?

Abstract

Ziwei Zhang1, Mingyu Bi2, Qi Liu1, Jie Yang1, Shiwen Xu1

1College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China

2Harbin Railway Public Security Bureau Police Dog Base, Harbin 150056, P. R. China

Correspondence to:

Shiwen Xu, email: [email protected]

Keywords: hepatocellular carcinoma, selenium, correlation, meta-analysis

Received: September 12, 2016 Accepted: October 14, 2016 Published: October 21, 2016

ABSTRACT

Hepatocellular carcinoma (HCC) is the most common cancer type. There is a correlation between selenium (Se) deficiency and the incidence of HCC. To clarify the effects of Se level on the risk of HCC patients, a meta-analysis was performed. A total of 9 articles published between 1994 and 2016 worldwide were selected through searching PubMed, EMBASE, web of science, Cochrane Library, Springer Link, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biology Medicine (CBM), and the information were analyzed using a meta-analysis method. Heterogeneity was assessed by using the I² index. Publication bias was evaluated by Begg’s Test analysis. Pooled analysis indicated that patients with HCC had lower Se levels than the healthy controls [standardized mean difference (SMD)= −1.08, 95% confidence intercal (CI) = (−0.136, −0.08), P < 0.001]. Further subgroup analysis showed this effect to be independent of the study design, race or sample collection. In conclusion, this meta-analysis suggested an inverse correlation between Se level and the risk of HCC in humans patients.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 12804

Publication Alerts

Research Papers:

Meta-analysis of the correlation between selenium and incidence of hepatocellular carcinoma

Abstract