Expression of CK19 is an independent predictor of negative outcome for patients with squamous cell carcinoma of the tongue
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Jutta Ernst1,*, Kristian Ikenberg2,*, Barbara Apel2, Desiree M. Schumann1, Gerhard Huber3, Gabriela Studer4, Tamara Rordorf5, Oliver Riesterer4, Matthias Rössle6, Dimitri Korol7, Marius G. Bredell1
1Department of Cranio-, Maxillofacial and Oral Surgery, University Hospital Zurich, Zürich, Switzerland
2Department of Pathology, University Hospital Zurich, Zürich, Switzerland
3Department of Otorhinolaryngology, University Hospital Zurich, Zürich, Switzerland
4Department of Radiation Oncology, University Hospital Zurich, Zürich, Switzerland
5Department of Oncology, University Hospital Zurich, Zürich, Switzerland
6Department of Pathology, Cantonal Hospital Chur, Chur, Switzerland
7Cancer Registry Zurich and Zug, University Hospital Zurich, Zürich, Switzerland
*These authors have contributed equally to this work
Marius G. Bredell, email: email@example.com
Keywords: tongue cancer, cytokeratin 19 (CK19), Ki-67, head and neck cancer (HNC)
Received: May 04, 2016 Accepted: September 12, 2016 Published: October 15, 2016
Objectives: To explore the prognostic role of CK19 expression in squamous cell carcinomas within a well-defined cohort of oral tongue cancer patients.
Methods: In our retrospective study, we investigated 129 patients with tongue cancer that had suitable material for inclusion in a tissue microarray (TMA). Where possible, samples were taken from central and peripheral regions of the tumor to generate a representative sample of the tumor. The expression level of CK19 was assessed by immunohistochemical staining.
Results: Expression of CK19 in squamous cell carcinoma of the tongue was identified as a negative predictor for overall survival (OS; p<0.000) and disease specific survival (DSS; p=0.001). No significant difference could be shown for disease free survival (DFS) between patients with positive and negative CK19 staining (p=.094).
Conclusion: This is the first description of the highly significant role of CK19 in a selective, organ specific head and neck cancer cohort. Our results are of special importance against the background that CK19 positive carcinomas revealed a significantly poorer prognosis and therefore emphasize its prognostic and possible diagnostic role in tongue cancer.
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