TNFAIP3 gene rs10499194, rs13207033 polymorphisms decrease the risk of rheumatoid arthritis

Ming-Jie Wang; Hao-Yu Yang; Hui Zhang; Xindie Zhou; Rui-Ping Liu; Yuan-Yuan Mi

doi:10.18632/oncotarget.12638

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

TNFAIP3 gene rs10499194, rs13207033 polymorphisms decrease the risk of rheumatoid arthritis

Ming-Jie Wang, Hao-Yu Yang, Hui Zhang, Xindie Zhou, Rui-Ping Liu _ and Yuan-Yuan Mi

PDF | HTML | How to cite

Oncotarget. 2016; 7:82933-82942. https://doi.org/10.18632/oncotarget.12638

Metrics: PDF 2587 views | HTML 2214 views | ?

Abstract

Ming-Jie Wang1,*, Hao-Yu Yang1,*, Hui Zhang1, Xindie Zhou1, Rui-Ping Liu1, Yuan-Yuan Mi2

1Department of Orthopedics, Affiliated Hospital of Nanjing Medical University, Changzhou Second People’s Hospital, Changzhou, China

2Department of Urology, The Third Affiliated Hospital of Nantong University, Wuxi, PR China

*These authors have contributed equally to this work

Correspondence to:

Rui-Ping Liu, email: [email protected]

Yuan-yuan Mi, email: [email protected]

Keywords: TNFAIP3, rheumatoid arthritis, meta-analysis, single nucleotide polymorphism

Received: August 08, 2016 Accepted: September 23, 2016 Published: October 13, 2016

ABSTRACT

Accumulating evidences suggested that tumor necrosis factor alpha inducible protein 3 (TNFAIP3) gene rs10499194, rs13207033 polymorphisms may be associated with the risk of rheumatoid arthritis (RA). However, these studies yielded contradictory findings. To clarify convincing associations, we conducted a comprehensive meta-analysis by searching in PubMed, Embase, and the China Knowledge Resource Integrated Database. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by using fixed-effect or random-effect models. A total of 13 case-control studies for rs10499194 polymorphism and 6 studies for rs13207033 polymorphism were included. Our data indicated that TNFAIP3 gene rs10499194, rs13207033 polymorphisms were associated with the decreased risk of RA. Stratification analyses of ethnicity indicated rs10499194, rs13207033 polymorphisms decreased the risk of RA among Caucasian populations, but not among Asian populations. In conclusion, this meta-analysis indicates that TNFAIP3 gene rs10499194, rs13207033 polymorphisms decrease the risk of RA, especially among Caucasian populations.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 12638

Publication Alerts

Research Papers:

TNFAIP3 gene rs10499194, rs13207033 polymorphisms decrease the risk of rheumatoid arthritis

Abstract