Research Papers:

Human cytomegalovirus infection and colorectal cancer risk: a meta-analysis

Bingjun Bai, Xingxing Wang, Engeng Chen and Hongbo Zhu _

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Oncotarget. 2016; 7:76735-76742. https://doi.org/10.18632/oncotarget.12523

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Bingjun Bai1,2, Xingxing Wang1,2, Engeng Chen1,2, Hongbo Zhu1,2

1Department of Colorectal Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China

2Key Laboratory of Biotherapy of Zhejiang province, Hangzhou, China

Correspondence to:

Hongbo Zhu, email: [email protected]

Keywords: HCMV, colorectal cancer, viral DNA, tumor progression, meta-analysis

Received: July 10, 2016     Accepted: October 03, 2016     Published: October 08, 2016


Human cytomegalovirus infection (HCMV) has been recently considered as a factor for tumorigenesis. The current study used meta-analytical techniques to explore the prevalence of HCMV in tumor tissues and the relationship between human cytomegalovirus and colorectal cancer (CRC) risk. 11 studies detecting HCMV DNA in tumor tissues were included in meta-analysis. The prevalence rate and odds ratio (OR) were two main parameters. The overall prevalence of human cytomegalovirus DNA in tumor tissues were 27.5% (95% CI = 17.2%−37.8%). Binary logistic regression showed that the studies reported before 2010 involving formalin-fixed specimens from patients in developed region represented a lower proportion of HCMV. The tumor tissues had a significantly higher rate of virus infection compared with normal tissues (OR = 6.59, 95% CI = 4.48−9.69, I2 = 0%, P = 0.71). Subgroup analysis revealed the prevalence of the virus didn’t differ in patients with different tumor stages, in tumor cells with different histologic grades, also in different kinds of specimen (polyp and adenocarcinoma). The results of current study suggested a statistically association between the virus infection and an increased risk of colorectal cancer.

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