Oncotarget

Research Papers:

Human beta-defensin 3 contributes to the carcinogenesis of cervical cancer via activation of NF-κB signaling

Dan Xu, Bing Zhang, Chongbing Liao, Wei Zhang, Weijia Wang, Ying Chang and Yongping Shao _

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Oncotarget. 2016; 7:75902-75913. https://doi.org/10.18632/oncotarget.12426

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Abstract

Dan Xu1,*, Bing Zhang1,*, Chongbing Liao2, Wei Zhang1, Weijia Wang2, Ying Chang1,2, Yongping Shao1,2

1Key Laboratory of Biomedical Information Engineering of the Ministry of Education, Department of Biological Science and Engineering, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi, China

2Center for Translational Medicine, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, China

*These authors have contributed equally to this work

Correspondence to:

Yongping Shao, email: yongping.shao@xjtu.edu.cn

Keywords: human beta-defensin 3, cervical cancer, carcinogenesis

Received: June 30, 2016    Accepted: September 21, 2016    Published: October 04, 2016

ABSTRACT

Human beta-defensin 3 (hBD3), an antimicrobial peptide (AMP) expressed in epithelium in response to various stimulations including human papillomavirus infection, has recently been found to be overexpressed in head and neck cancers and exhibit tumorigenic activities. However, the role of hBD3 in cervical cancer remains to be investigated. In this study, we showed by immunohistochemistry that hBD3 expression was elevated in cervical cancer samples of different stages versus the normal tissue, and was positively correlated with the progression of the disease. Overexpression of hBD3 in cervical cancer cell lines promoted cell proliferation by accelerating G1/S progression and enhanced cell migration and invasion in vitro. These oncogenic effects of hBD3 were associated with activation of NF-κB signaling. Using a mouse xenograft model, we further demonstrated that hBD3 overexpression promoted the growth of cervical cancer cells in vivo. Our results suggested that hBD3 is involved in the carcinogenesis and development of cervical cancer, and may serve as a biomarker or therapeutic target of this disease.


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