Myricetin, a potent natural agent for treatment of diabetic skin damage by modulating TIMP/MMPs balance and oxidative stress
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Zijian Wu1,*, Xuemin Zheng2,*, Min Gong4,5,*, Ying Li3,*
1Tianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China
2Tianjin Institute of Pharmaceutical Research, Tianjin, China
3Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
4Department of Pharmacy, Tianjin Medical University, Tianjin, China
5Department of Oncology, University of Oxford, Oxford, UK
*These authors contributed equally to this work
Zijian Wu, email: [email protected]
Min Gong, email: [email protected]
Ying Li, email: [email protected]
Keywords: myricetin, diabetic fibroblast, high glucose, oxidative stress, MMP
Received: July 28, 2016 Accepted: September 22, 2016 Published: September 28, 2016
Foot ulceration is a major cause of morbidity in patients with diabetes, and abnormal peripheral neuropathy often results in hospitalization. Up-regulation of matrix metalloproteinases and down-regulation of tissue inhibitor of metalloproteinase 1 are noted to be distinctive biological functions of diabetic dermal fibroblasts. The aim of this study was to evaluate the biological effects of modified retinoids on diabetic fibroblasts. Myricetin, a natural compound, balances the TIMP1/MMP ratio and oxidative stress in diabetic fibroblasts. Our results indicate that myricetin significantly ameliorates the effects of diabetes on dermal fibroblasts. In addition, we found that the oxidative stress imbalance induced by a high glucose concentration plays an important role in the changes to dermal fibroblasts that occur in diabetes. Our findings support the hypothesis that myricetin has the potential to repair faulty skin function arising from diabetes.
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