Oncotarget

Research Papers:

Myricetin, a potent natural agent for treatment of diabetic skin damage by modulating TIMP/MMPs balance and oxidative stress

Zijian Wu, Xuemin Zheng, Min Gong and Ying Li _

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Oncotarget. 2016; 7:71754-71760. https://doi.org/10.18632/oncotarget.12330

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Abstract

Zijian Wu1,*, Xuemin Zheng2,*, Min Gong4,5,*, Ying Li3,*

1Tianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China

2Tianjin Institute of Pharmaceutical Research, Tianjin, China

3Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China

4Department of Pharmacy, Tianjin Medical University, Tianjin, China

5Department of Oncology, University of Oxford, Oxford, UK

*These authors contributed equally to this work

Correspondence to:

Zijian Wu, email: wzjian@tjcu.edu.cn

Min Gong, email: kahongmg@163.com

Ying Li, email: liying11_@hotmail.com

Keywords: myricetin, diabetic fibroblast, high glucose, oxidative stress, MMP

Received: July 28, 2016     Accepted: September 22, 2016     Published: September 28, 2016

ABSTRACT

Foot ulceration is a major cause of morbidity in patients with diabetes, and abnormal peripheral neuropathy often results in hospitalization. Up-regulation of matrix metalloproteinases and down-regulation of tissue inhibitor of metalloproteinase 1 are noted to be distinctive biological functions of diabetic dermal fibroblasts. The aim of this study was to evaluate the biological effects of modified retinoids on diabetic fibroblasts. Myricetin, a natural compound, balances the TIMP1/MMP ratio and oxidative stress in diabetic fibroblasts. Our results indicate that myricetin significantly ameliorates the effects of diabetes on dermal fibroblasts. In addition, we found that the oxidative stress imbalance induced by a high glucose concentration plays an important role in the changes to dermal fibroblasts that occur in diabetes. Our findings support the hypothesis that myricetin has the potential to repair faulty skin function arising from diabetes.


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