Gene polymorphisms are associated with clinical outcome in Chinese resected laryngeal carcinoma patients
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Peng Chen1,2,3,*, Zhengshuai Chen1,2,*, Jinglie Li1,2, Hua Yang1,2, Yuanyuan Zhu2, Ning Zhang2, Mengdan Yan1,2, Yuan Shao4, Chao Chen1,2, Tianbo Jin1,2
1The National Engineering Research Centre for Miniaturized Detection Systems, College of Life Science, Northwest University, Xi’an, Shaanxi 710069, China
2Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi’an, Shaanxi 710069, China
3Institution of Basic Medical Science, Xi'an Medical University, Xi'an, Shaanxi 710021, China
4Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Xi'an, Jiaotong University, Xi'an, Shaanxi 710061, China
*Joint first authors
Tianbo Jin, email: [email protected]
Chao Chen, email: [email protected]
Keywords: single-nucleotide polymorphism, laryngeal carcinoma, overall survival, prognosis, prognostic marker
Received: July 25, 2016 Accepted: September 22, 2016 Published: September 28, 2016
We examined the multigenetic index on the progression of laryngeal carcinoma in Chinese population. This study aims to assess the effects of single nucleotide polymorphisms (SNPs) on survival of Laryngeal Carcinoma (LC) patients. Eighteen SNPs were selected and genotyped using the Sequenom iPLEX genotyping system in a cohort of 170 resected Chinese LC patients. Multivariate Cox proportional hazards model and Kaplan-Meier curve were used for the prognosis analysis. Overall, the median survival time (MST) was 38.00 months. The one, three and five year Kaplan-Meier survival rate was 0.847 ± 0.028, 0.572 ± 0.038 and 0.471 ± 0.041 respectively. The risks of death with the Hazard Ratio (HR) [95% confidence intervals] (CI) of 2.40 (1.15–4.50), 2.17 (1.45–3.25), 2.39 (1.58–3.62), 3.29 (2.10–5.18), respectively. There was significant associations between the SNPs and OS when the entire study population was examined. The rs1321311 TG genotype (vs.GG), rs2494938 AA genotype (vs. GG) and rs9363918 TG genotype (vs. GG) were associated with a worse prognosis for OS (adjusted HR = 1.64; 95%confidence interval = 1.07–2.51; P = 0.022, adjusted HR = 2.85; P =0.12; adjusted HR = 1.78; P = 0.009; respectively).
The results suggest for the first time that these gene polymorphisms may serve as an independent prognostic marker for LC patients.
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