ADH1B and CDH1 polymorphisms predict prognosis in male patients with non-metastatic laryngeal cancer
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Daxu Li1,*, Ruizhi Zhang2,*, Tianbo Jin3, Na He3, Le Ren1, Zhe Zhang1, Qingna Zhang1, Ran Xu1, Hong Tao1, Guang Zeng4, Jing Gao5
1Department of Stomatology, First Affiliated Hospital, Xi’an Jiaotong University School of Medicine, Xi’an, Shaanxi 710061, China
2Department of Stomatology, Ankang Central Hospital, Ankang 725000, Shaanxi, China
3School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China
4Department of Plastic and Burn Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, Shaanxi 710038, China
5State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi 710032, China
*These authors contributed equally to this work
Jing Gao, email: [email protected]
Guang Zeng, email: [email protected]
Keywords: laryngeal cancer, polymorphism, prognosis, ADH1B, CDH1
Received: May 31, 2016 Accepted: September 20, 2016 Published: September 28, 2016
In this study, we assessed the association between single nucleotide polymorphisms (SNPs) in candidate genes and the prognosis of laryngeal cancer (LC) patients. Thirty-seven SNPs in 26 genes were genotyped in 170 male Han Chinese patients with LC. The effects of the candidate genes on the prognosis of LC patients were evaluated using Kaplan-Meier curves and Cox proportional hazards regression models. The GA genotype of rs1229984 (hazard ratio [HR], 0.537; 95% confidence interval [CI], 0.340–0.848; p = 0.008) in alcohol dehydrogenase 1B (ADH1B), and the AA genotype of rs9929218 (HR, 6.074; 95% CI, 1.426–25.870; p = 0.015) in CDH1 were associated with overall survival. Our data suggest that polymorphisms in ADH1B and CDH1 may be prognostic indicators in LC.
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