Oncotarget

Research Papers:

The pathological behaviors and prognostic factors of Chinese and Japanese colorectal cancers from general hospitals: a comparative study of the inpatients with surgical operation

Xue-feng Yang, Ji-feng Zhang, Jun-jun Li, Shuang Zhao, Shuai Shi, Ji-cheng Wu, Lei Fang, Hua-mao Jiang and Hua-chuan Zheng _

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Oncotarget. 2016; 7:84155-84164. https://doi.org/10.18632/oncotarget.12228

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Abstract

Xue-feng Yang1, Ji-feng Zhang1, Jun-jun Li1, Shuang Zhao1, Shuai Shi1, Ji-cheng Wu1, Lei Fang1, Hua-mao Jiang2, Hua-chuan Zheng1,3

1Cancer Center, Key Laboratory of Brain and Spinal Cord Injury of Liaoning Province, and Animal Center, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, China

2Department of Urology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, China

3Life Science Institute of Jinzhou Medical University, Jinzhou 121001, China

Correspondence to:

Hua-chuan Zheng, email: zheng_huachuan@hotmail.com

Keywords: colorectal cancers, pathological behaviors, prognosis, China, Japan

Received: May 29, 2016     Accepted: August 25, 2016     Published: September 24, 2016

ABSTRACT

Here, we collected the information of 17304 and 2014 inpatients with colorectal cancer (CRC) from general hospitals of China and Japan respectively, and analyzed microscopic and macroscopic aspects, even stratified by the age and gender. It was found that Chinese CRC patients showed younger prone, more rectal and ascending cancers, less sigmoid and transverse cancers, larger size, less invasion into lymphatic system or metastasis into lymph node, and poorer differentiation than Japanese ones (p < 0.05). TNM staging was employed as an independent factor for the prognosis of the CRC patients regardless of the country (p < 0.05). Female patients showed larger tumor size, easier invasion and metastasis into lymphatic system, and worse differentiation than males (p < 0.05). The younger patients displayed frequent invasion and metastasis into lymphatic system, and poor differentiation in comparison to elder ones (p < 0.05). These findings demonstrated that Japanese patients seemed to have more invasion and metastasis due to standard and precise operation and pathological diagnosis accuracy. Actually, Chinese patients had more aggressive pathological characteristics and a poorer prognosis. Therefore, it is essential to establish a routine screening methodology, a standard treatment system and postoperative diagnosis protocol for the prevention and therapeutics of Chinese CRC patients, especially for female and young patients.


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