Associations of P16 INK4a  promoter hypermethylation with squamous intra-epithelial lesion, cervical cancer and their clinicopathological features: a meta-analysis

Ya-di Han; Xue-bin Wang; Ning-hua Cui; Shuai Zhang; Chen Wang; Fang Zheng

doi:10.18632/oncotarget.12202

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Associations of P16^INK4a promoter hypermethylation with squamous intra-epithelial lesion, cervical cancer and their clinicopathological features: a meta-analysis

Ya-di Han, Xue-bin Wang, Ning-hua Cui, Shuai Zhang, Chen Wang and Fang Zheng _

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Oncotarget. 2017; 8:1871-1883. https://doi.org/10.18632/oncotarget.12202

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Abstract

Ya-di Han1,*, Xue-bin Wang1*, Ning-hua Cui2, Shuai Zhang1, Chen Wang1 and Fang Zheng1

1 Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China

2 Department of Clinical Laboratory, Children’s Hospital of Zhengzhou, Zhengzhou, Henan, China

* These authors have contributed equally to this work

Correspondence to:

Fang Zheng, email:

Keywords: cervical cancer, squamous intra-epithelial lesion, P16^INK4a promoter hypermethylation, smoking habit, meta-analysis

Received: June 04, 2016 Accepted: September 16, 2016 Published: September 22, 2016

Abstract

To assess the associations of P16INK4a methylation status with low-grade squamous intra-epithelial lesion (LSIL), high-grade squamous intra-epithelial lesion (HSIL), cervical cancer (CC) and their clinicopathological features, a meta-analysis with 29 eligible studies was conducted. Pooled odds ratios (ORs) with their 95% confidence intervals (CIs) were estimated to assess the strength of the associations. Heterogeneity, sensitivity of pooled results and publication bias were also evaluated. Overall, there was an increasing trend of P16INK4a hypermethylation rates among LSIL (21.4%), HSIL (30.9%) and CC (35.0%) specimens. P16INK4a hypermethylation was significantly associated with the increased risk of LSIL, HSIL and CC, with the pooled ORs of 3.26 (95% CI: 1.86-5.71), 5.80 (95% CI: 3.80-8.84) and 12.17 (95% CI: 5.86-25.27), respectively. A significant association was also found between P16INK4a hypermethylation and smoking habit (OR = 3.88, 95% CI: 2.13-7.08). Taken together, meta-analysis results support P16INK4a hypermethylation as an epigenetic marker for the progression of cervical carcinogenesis.

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Associations of P16INK4a promoter hypermethylation with squamous intra-epithelial lesion, cervical cancer and their clinicopathological features: a meta-analysis

Abstract

Associations of P16^INK4a promoter hypermethylation with squamous intra-epithelial lesion, cervical cancer and their clinicopathological features: a meta-analysis