Research Papers:

A dose increased once-weekly bortezomib-based combination therapy for multiple myeloma

Daolin Wei, Yin Tong, Haitao Bai, Qi Cai, Yanrong Gao and Chun Wang _

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Oncotarget. 2016; 7:70168-70174. https://doi.org/10.18632/oncotarget.12162

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Daolin Wei1, Yin Tong1, Haitao Bai1, Qi Cai1, Yanrong Gao1, Chun Wang1

1Department of Hematology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, China

Correspondence to:

Chun Wang, email: [email protected]

Keywords: multiple myeloma, bortezomib, response rate, adverse event

Received: April 21, 2016     Accepted: September 14, 2016     Published: September 21, 2016


Background: The purpose of the current study was to evaluate the efficacy and safety of a dose increased weekly Bortezomib (Bor) based combination therapy in multiple myeloma (MM) patients.

Results: The overall response rate (ORR) in the modified Bor group was 76.6%, composed of 40% complete response (CR), 3.3% very good partial response (VGPR) and 33.3% partial response (PR). The ORR was 82.3%, with 26.5% CR, 5.9% VGPR and 50% PR in control. A subgroup analysis showed both groups had equal efficacy in newly diagnosed MM patients ( P = 1.000). The median progression free survival was 16 (11.7–20.3) months for the modified Bor group and 12 (10.5–13.5) months for the control (P = 0.503), and the median overall survival was 36 (9.4–62.6) vs 28 (21.6–34.4) months (P = 0.759). The incidences of AEs were similar except grade 1–4 peripheral neuropathy (PN) rate was 10% in modified regime group and 32.4% in control (P = 0.038).

Materials and Methods: This was a monocentric, prospective, non-randomized, phase IV, non-inferiority trial. Thirty MM patients were treated with modified Bor-based combination therapy (Bor 1.6 mg/m2 on day 1, 8), with 34 MM patients on conventional Bor-based combination therapy (1.3 mg/m2 on day 1, 4, 8, 11) as control. The responses and adverse events (AEs) were compared.

Conclusions: The increased-dose weekly Bor-based combination therapies were not inferior to conventional ones in terms of response and survival benefit, but showed lower rate of peripheral neuropathy (PN).

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