Oncotarget

Research Papers:

The clinicopathologic relevance and prognostic value of tumor deposits and the applicability of N1c category in rectal cancer with preoperative radiotherapy

Xiao-li Wei, Miao-zhen Qiu, Yi-xin Zhou, Ming-ming He, Hui-yan Luo, Feng-hua Wang, Dong-sheng Zhang, Yu-hong Li and Rui-hua Xu _

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Oncotarget. 2016; 7:75094-75103. https://doi.org/10.18632/oncotarget.12058

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Abstract

Xiao-li Wei1,*, Miao-zhen Qiu1,2,*, Yi-xin Zhou1,*, Ming-ming He1, Hui-yan Luo1, Feng-hua Wang1, Dong-sheng Zhang1, Yu-hong Li1, Rui-hua Xu1

1Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China

2Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA

*These authors have contributed equally to this work

Correspondence to:

Rui-Hua Xu, email: xurh@sysucc.org.cn

Keywords: rectal cancer, tumor deposits, preoperative radiotherapy, prognosis, SEER

Received: March 02, 2016     Accepted: August 24, 2016     Published: September 16, 2016

ABSTRACT

The clinicopathologic relevance and prognostic value of tumor deposits in colorectal cancer has been widely demonstrated. However, there are still debates in the prognostic value of tumor deposits and the applicability of N1c category in rectal cancer with preoperative radiotherapy. In this study, rectal cancer with preoperative radiotherapy followed by resection of primary tumors registered in Surveillance, Epidemiology and End Results (SEER) database from 2010-2012 were analyzed. There were 4,813 cases eligible for this study, and tumor deposits were found in 514 (10.7%) cases. The presence of tumor deposits was significantly associated with some aggressive characteristics, including poorer tumor differentiation, more advanced ypT category, ypN category and ypTNM stage, distant metastasis, elevated carcinoembryonic antigen, higher positive rates of circumferential resection margin and perineural invasion (all P < = 0.001). Tumor deposit was also an independent negative prognostic factor for cancer-specific survival in rectal cancer with preoperative radiotherapy (adjusted HR and 95% CI: 2.25 (1.51 – 3.35)). N1c category had significant worse survival compared with N0 category (adjusted HR and 95% CI: 2.41 (1.24 – 4.69)). In conclusion, tumor deposit was a significant and independent prognostic factor, and the N1c category by the 7th edition of AJCC/TNM staging system was applicable in rectal cancer with preoperative radiotherapy.


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