Prognostic and clinicopathological value of Gli-1 expression in gastric cancer: A meta-analysis

Li Lu, Menglin Wu, Feixiang Zhao, Weihua Fu, Weidong Li, Xue Li and Tong Liu _

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Oncotarget. 2016; 7:69087-69096. https://doi.org/10.18632/oncotarget.12011

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Li Lu1,*, Menglin Wu2,*, Feixiang Zhao2, Weihua Fu1, Weidong Li1, Xue Li2 and Tong Liu1

1 Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China

2 Department of Radiology, Second Hospital of Tianjin Medical University,Tianjin, China

* These authors contributed equally to this work, thus they are co-first author

Correspondence to:

Tong Liu, email:

Xue Li, email:

Keywords: Gli-1, gastric cancer, prognosis

Received: June 29, 2016 Accepted: September 05, 2016 Published: September 13, 2016


Glioma associated oncogene-1 (Gli-1) is considered as a strong positive activator of downstream target genes of hedgehog signal pathway in mammalians. However, its diagnostic and prognostic value in gastric cancer remains unclear and controversial. Therefore, a quantitative meta-analysis was conducted to determine the clinical value of Gli-1 in gastric cancer patients. Twelve eligible articles with 886 gastric cancer patients were included in this meta-analysis. The relationship between Gli-1 expression in gastric cancer patients and clinicopathological features and 5-year overall survival (OS) was evaluated using pooled odds ratios (ORs) and hazard ratio (HR) with 95% confidence intervals (CIs). The meta-analysis showed that the upregulated Gli-1 was associated with sample type (gastric cancer tissues) (OR 10.31, 95%CI 7.14-14.88; P = 0.000), differentiation type (OR 3.76, 95%CI 2.55-5.53; P = 0.000), depth of invasion (OR 8.17, 95%CI 3.60-18.55; P = 0.000), lymph node metastasis (OR 3.97, 95%CI 2.73-5.78; P = 0.000) and high TNM stage (OR 3.65, 95%CI 1.89-7.04; P = 0.000). Three studies including 316 patients were assessed for the correlation between Gli-1 and 5-year OS, which indicated that positive Gli-1 expression was associated with poor prognosis in gastric cancer patients (HR 2.14, 95%CI 1.35-3.40; P = 0.001). Little publication bias was identified by funnel plots and Egger’s tests. The sensitivity analysis indicated that no study substantially influenced pooled OR/HR. Taken together, Gli-1 is a credible indicator for highly aggressive tumor with poor prognosis in gastric cancer patients.

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